Decrease of FZD4 exon 1 methylation in probands from FZD4-associated FEVR family of phenotypic heterogeneity

Decrease of FZD4 exon 1 methylation in probands from FZD4-associated FEVR family of phenotypic heterogeneity

Familial exudative vitreoretinopathy (FEVR) is an important cause of childhood blindness and is clinically characterized by phenotypic heterogeneity. FEVR patients harboring the same genetic mutation vary widely in disease severity. The purpose of this study was to explore non-genetic factors that r...

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Bibliographic Details
Main Authors: Miaomiao Liu, Jia Luo, Huazhang Feng, Jing Li, Xiang Zhang, Peiquan Zhao, Ping Fei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Medicine
Subjects:
familial exudative vitreoretinopathy (FEVR)
the receptor frizzled-4 (FZD4)
phenotypic heterogeneity
DNA methylation
epigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.976520/full

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