Nucleocapsid as a next-generation COVID-19 vaccine candidate
Multiple new variants of the SARS-CoV-2 virus have emerged globally, due to viral mutation. The majority of COVID-19 vaccines contain SARS-CoV-2 spike protein, which is susceptible to mutation. It is known that protection against COVID-19 after two doses of mRNA vaccine continuously wanes over time....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222003794 |
| _version_ | 1811297429253783552 |
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| author | Bryan Oronsky Christopher Larson Scott Caroen Farah Hedjran Ana Sanchez Elena Prokopenko Tony Reid |
| author_facet | Bryan Oronsky Christopher Larson Scott Caroen Farah Hedjran Ana Sanchez Elena Prokopenko Tony Reid |
| author_sort | Bryan Oronsky |
| collection | DOAJ |
| description | Multiple new variants of the SARS-CoV-2 virus have emerged globally, due to viral mutation. The majority of COVID-19 vaccines contain SARS-CoV-2 spike protein, which is susceptible to mutation. It is known that protection against COVID-19 after two doses of mRNA vaccine continuously wanes over time. If viral variants contain mutated spike protein, current vaccines may not provide robust protection. This perspective suggests the inclusion of SARS-CoV-2 nucleocapsid protein in future COVID-19 vaccines and boosters, as nucleocapsid is much less vulnerable to mutation and may provide stronger immunity to novel viral variants. |
| first_indexed | 2024-04-13T06:04:10Z |
| format | Article |
| id | doaj.art-534e296d80534e5ca97787581486c7c2 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-13T06:04:10Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-534e296d80534e5ca97787581486c7c22022-12-22T02:59:20ZengElsevierInternational Journal of Infectious Diseases1201-97122022-09-01122529530Nucleocapsid as a next-generation COVID-19 vaccine candidateBryan Oronsky0Christopher Larson1Scott Caroen2Farah Hedjran3Ana Sanchez4Elena Prokopenko5Tony Reid6EpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USA; Corresponding author.EpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USAEpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USAEpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USAEpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USAEpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USAEpicentRx, Inc., 11099 North Torrey Pines Road Suite 160, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, 3855 Health Sciences Dr., La Jolla, CA, 92037, USAMultiple new variants of the SARS-CoV-2 virus have emerged globally, due to viral mutation. The majority of COVID-19 vaccines contain SARS-CoV-2 spike protein, which is susceptible to mutation. It is known that protection against COVID-19 after two doses of mRNA vaccine continuously wanes over time. If viral variants contain mutated spike protein, current vaccines may not provide robust protection. This perspective suggests the inclusion of SARS-CoV-2 nucleocapsid protein in future COVID-19 vaccines and boosters, as nucleocapsid is much less vulnerable to mutation and may provide stronger immunity to novel viral variants.http://www.sciencedirect.com/science/article/pii/S1201971222003794COVID-19SARS-CoV-2VaccineNucleocapsid |
| spellingShingle | Bryan Oronsky Christopher Larson Scott Caroen Farah Hedjran Ana Sanchez Elena Prokopenko Tony Reid Nucleocapsid as a next-generation COVID-19 vaccine candidate International Journal of Infectious Diseases COVID-19 SARS-CoV-2 Vaccine Nucleocapsid |
| title | Nucleocapsid as a next-generation COVID-19 vaccine candidate |
| title_full | Nucleocapsid as a next-generation COVID-19 vaccine candidate |
| title_fullStr | Nucleocapsid as a next-generation COVID-19 vaccine candidate |
| title_full_unstemmed | Nucleocapsid as a next-generation COVID-19 vaccine candidate |
| title_short | Nucleocapsid as a next-generation COVID-19 vaccine candidate |
| title_sort | nucleocapsid as a next generation covid 19 vaccine candidate |
| topic | COVID-19 SARS-CoV-2 Vaccine Nucleocapsid |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222003794 |
| work_keys_str_mv | AT bryanoronsky nucleocapsidasanextgenerationcovid19vaccinecandidate AT christopherlarson nucleocapsidasanextgenerationcovid19vaccinecandidate AT scottcaroen nucleocapsidasanextgenerationcovid19vaccinecandidate AT farahhedjran nucleocapsidasanextgenerationcovid19vaccinecandidate AT anasanchez nucleocapsidasanextgenerationcovid19vaccinecandidate AT elenaprokopenko nucleocapsidasanextgenerationcovid19vaccinecandidate AT tonyreid nucleocapsidasanextgenerationcovid19vaccinecandidate |