Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans

Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans

Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights in this matter, we conducted a randomized cross-over design...

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Bibliographic Details
Main Authors:	Andreas Schittny, Samuel Waldner, Urs Duthaler, Alexander Vorobyev, Rimma Abramovich, Stephan Krähenbühl, Maxim Puchkov, Jörg Huwyler
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Pharmaceutics
Subjects:	amorphous solid dispersions bioavailability poorly soluble drugs clinical study hot-melt extrusion
Online Access:	https://www.mdpi.com/1999-4923/13/3/401

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