The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study
Abstract Background Survival and reconstruction constitute important challenges in multimodal treatment of osteosarcoma of the proximal tibia. The purpose of this study was to assess the efficacy and prognosis of neoadjuvant chemotherapy and custom-designed endoprosthetic arthroplasty. Methods A tot...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12891-018-2245-x |
| _version_ | 1817997326048821248 |
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| author | Junqi Huang Wenzhi Bi Gang Han Jinpeng Jia Meng Xu Wei Wang |
| author_facet | Junqi Huang Wenzhi Bi Gang Han Jinpeng Jia Meng Xu Wei Wang |
| author_sort | Junqi Huang |
| collection | DOAJ |
| description | Abstract Background Survival and reconstruction constitute important challenges in multimodal treatment of osteosarcoma of the proximal tibia. The purpose of this study was to assess the efficacy and prognosis of neoadjuvant chemotherapy and custom-designed endoprosthetic arthroplasty. Methods A total of 69 patients with osteosarcoma of the proximal tibia were evaluated, including 43 males and 26 females, treated with multidisciplinary limb-salvage remedy from October 2003 to December 2013. They were at least 12 years old (mean, 20 years; range, 12–57 years). The gap between tumor and main artery/nerve was showed in MRI. Mean follow up was 69.5 months (range, 9–144 months). Kaplan-Meier survival curves were generated to assess prognosis and relapse rate. The initial symptoms and disease duration for each patient were recorded. Correlation analyses were performed for the association of various parameters with prognosis. Functional outcomes were evaluated using the Musculoskeletal Tumor Society (MSTS) guidelines after 6 months postoperatively, to analyze the relation between bone excision size and function recovery. Results The resection lengths measured intraoperatively ranged from 80 to 230 mm, and contained 3 cm of normal bone around the tumor. A total of 3 courses of preoperative chemotherapy were administered to all cases. At final follow-up, 1 case showed recurrence. Meanwhile, 8 patients (11.6%) died from lung metastasis. Post-operative infection occurred in 3 patients; 1 case was maintained with revision surgery. Two cases underwent amputation. The mean MSTS system score was 21.6. Conclusions The multidisciplinary treatment result in an overall positive outcome, with improved function. |
| first_indexed | 2024-04-14T02:36:32Z |
| format | Article |
| id | doaj.art-534e5da3c62b4379ac7f4caf30a9a680 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-14T02:36:32Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-534e5da3c62b4379ac7f4caf30a9a6802022-12-22T02:17:24ZengBMCBMC Musculoskeletal Disorders1471-24742018-09-011911610.1186/s12891-018-2245-xThe multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective studyJunqi Huang0Wenzhi Bi1Gang Han2Jinpeng Jia3Meng Xu4Wei Wang5Department of Orthopaedics, Mianyang Central HospitalDepartment of Orthopaedics, PLA General HospitalDepartment of Orthopaedics, PLA General HospitalDepartment of Orthopaedics, PLA General HospitalDepartment of Orthopaedics, PLA General HospitalDepartment of Orthopaedics, PLA General HospitalAbstract Background Survival and reconstruction constitute important challenges in multimodal treatment of osteosarcoma of the proximal tibia. The purpose of this study was to assess the efficacy and prognosis of neoadjuvant chemotherapy and custom-designed endoprosthetic arthroplasty. Methods A total of 69 patients with osteosarcoma of the proximal tibia were evaluated, including 43 males and 26 females, treated with multidisciplinary limb-salvage remedy from October 2003 to December 2013. They were at least 12 years old (mean, 20 years; range, 12–57 years). The gap between tumor and main artery/nerve was showed in MRI. Mean follow up was 69.5 months (range, 9–144 months). Kaplan-Meier survival curves were generated to assess prognosis and relapse rate. The initial symptoms and disease duration for each patient were recorded. Correlation analyses were performed for the association of various parameters with prognosis. Functional outcomes were evaluated using the Musculoskeletal Tumor Society (MSTS) guidelines after 6 months postoperatively, to analyze the relation between bone excision size and function recovery. Results The resection lengths measured intraoperatively ranged from 80 to 230 mm, and contained 3 cm of normal bone around the tumor. A total of 3 courses of preoperative chemotherapy were administered to all cases. At final follow-up, 1 case showed recurrence. Meanwhile, 8 patients (11.6%) died from lung metastasis. Post-operative infection occurred in 3 patients; 1 case was maintained with revision surgery. Two cases underwent amputation. The mean MSTS system score was 21.6. Conclusions The multidisciplinary treatment result in an overall positive outcome, with improved function.http://link.springer.com/article/10.1186/s12891-018-2245-xOsteosarcomaTibiaArthroplastyReconstructionSurvival |
| spellingShingle | Junqi Huang Wenzhi Bi Gang Han Jinpeng Jia Meng Xu Wei Wang The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study BMC Musculoskeletal Disorders Osteosarcoma Tibia Arthroplasty Reconstruction Survival |
| title | The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study |
| title_full | The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study |
| title_fullStr | The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study |
| title_full_unstemmed | The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study |
| title_short | The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study |
| title_sort | multidisciplinary treatment of osteosarcoma of the proximal tibia a retrospective study |
| topic | Osteosarcoma Tibia Arthroplasty Reconstruction Survival |
| url | http://link.springer.com/article/10.1186/s12891-018-2245-x |
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