Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort

Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort

Abstract Background Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascular health, with high levels reflecting poor vitamin K status. The occurrence of extra-hepatic vitamin K deficiency throughout the disease of COVID-19 and pos...

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Bibliographic Details
Main Authors: Mark M. G. Mulder, Joep Schellens, Jan-Willem E. M. Sels, Frank van Rosmalen, Anne-Marije Hulshof, Femke de Vries, Ruud Segers, Casper Mihl, Walther N. K. A. van Mook, Aalt Bast, Henri M. H. Spronk, Yvonne M. C. Henskens, Iwan C. C. van der Horst, Hugo ten Cate, Leon J. Schurgers, Marjolein Drent, Bas C. T. van Bussel
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Intensive Care
Subjects:
Vitamin K deficiency
Matrix Gla protein
COVID-19
Intensive care
Pulmonary embolism
Online Access:https://doi.org/10.1186/s40560-023-00712-0

Internet

https://doi.org/10.1186/s40560-023-00712-0

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