Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease

Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease

Summary: Paneth cells (PC) play a key role in the innate immune response of intestine epithelium, and PC defects contribute to the pathogenesis of Crohn’s disease (CD). In this study, we utilized active CD tissues and advanced oxidation protein products (AOPP)-challenged C57BL/6 mouse model to inves...

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Bibliographic Details
Main Authors: Jie Shi, Weidong Wang, Shibo Sun, Xiaoping Xu, Jieying Fei, Qian Zhou, Caolitao Qin, Shiyu Ou, Fengfei Wu, Fang ting Wu, Tianyan Xu, Lan Bai, Fang Xie
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223013895

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