The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study
Background: Glomerular hyperfiltration has been reported to be associated with adverse renal outcomes in the general population. It is not known whether drinking pattern is associated with the risk of glomerular hyperfiltration in healthy individuals. Methods: We prospectively followed middle-aged 8...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2024-03-01
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| Series: | Journal of Epidemiology |
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| Online Access: | https://www.jstage.jst.go.jp/article/jea/34/3/34_JE20220312/_pdf |
| _version_ | 1827329667550412800 |
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| author | Mikiko Shibata Kyoko Kogawa Sato Hideo Koh Izumi Shibata Kaori Okamura Yuka Takeuchi Keiko Oue Michio Morimoto Tomoshige Hayashi |
| author_facet | Mikiko Shibata Kyoko Kogawa Sato Hideo Koh Izumi Shibata Kaori Okamura Yuka Takeuchi Keiko Oue Michio Morimoto Tomoshige Hayashi |
| author_sort | Mikiko Shibata |
| collection | DOAJ |
| description | Background: Glomerular hyperfiltration has been reported to be associated with adverse renal outcomes in the general population. It is not known whether drinking pattern is associated with the risk of glomerular hyperfiltration in healthy individuals. Methods: We prospectively followed middle-aged 8,640 Japanese men with normal renal function, no proteinuria, no diabetes, and no use of antihypertensive medications at entry. Data on alcohol consumption were gathered by questionnaire. Glomerular hyperfiltration was defined as estimated glomerular filtration rate (eGFR) ≥117 mL/min/1.73 m2, which was the upper 2.5th percentile value of eGFR in the entire cohort. Results: During 46,186 person-years of follow-up, 330 men developed glomerular hyperfiltration. In a multivariate model, for men who consumed alcohol on 1–3 days per week, alcohol consumption of ≥69.1 g ethanol/drinking day was significantly associated with the risk of glomerular hyperfiltration (hazard ratio [HR] 2.37; 95% confidence interval [CI], 1.18–4.74) compared with non-drinkers. For those who consumed alcohol on 4–7 days per week, higher alcohol consumption per drinking day was associated with a higher risk of glomerular hyperfiltration: the HRs for alcohol consumption of 46.1–69.0, and ≥69.1 g ethanol/drinking day were 1.55 (95% CI, 1.01–2.38), and 1.78 (95% CI, 1.02–3.12), respectively. Conclusion: For high drinking frequency per week, more alcohol intake per drinking day was associated with an increased risk of glomerular hyperfiltration, while for low drinking frequency per week, only very high alcohol intake per drinking day was associated with an increased risk of glomerular hyperfiltration in middle-aged Japanese men. |
| first_indexed | 2024-03-07T15:44:24Z |
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| id | doaj.art-5352dccda9e24133b7bd808d60f4e4a2 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-03-07T15:44:24Z |
| publishDate | 2024-03-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-5352dccda9e24133b7bd808d60f4e4a22024-03-05T04:43:51ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922024-03-0134313714310.2188/jea.JE20220312The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare StudyMikiko Shibata0Kyoko Kogawa Sato1Hideo Koh2Izumi Shibata3Kaori Okamura4Yuka Takeuchi5Keiko Oue6Michio Morimoto7Tomoshige Hayashi8Preventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanHealth Administration Center (Kansai region), Nippon Telegraph and Telephone West Corporation, Osaka, JapanHealth Administration Center (Kansai region), Nippon Telegraph and Telephone West Corporation, Osaka, JapanPreventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanBackground: Glomerular hyperfiltration has been reported to be associated with adverse renal outcomes in the general population. It is not known whether drinking pattern is associated with the risk of glomerular hyperfiltration in healthy individuals. Methods: We prospectively followed middle-aged 8,640 Japanese men with normal renal function, no proteinuria, no diabetes, and no use of antihypertensive medications at entry. Data on alcohol consumption were gathered by questionnaire. Glomerular hyperfiltration was defined as estimated glomerular filtration rate (eGFR) ≥117 mL/min/1.73 m2, which was the upper 2.5th percentile value of eGFR in the entire cohort. Results: During 46,186 person-years of follow-up, 330 men developed glomerular hyperfiltration. In a multivariate model, for men who consumed alcohol on 1–3 days per week, alcohol consumption of ≥69.1 g ethanol/drinking day was significantly associated with the risk of glomerular hyperfiltration (hazard ratio [HR] 2.37; 95% confidence interval [CI], 1.18–4.74) compared with non-drinkers. For those who consumed alcohol on 4–7 days per week, higher alcohol consumption per drinking day was associated with a higher risk of glomerular hyperfiltration: the HRs for alcohol consumption of 46.1–69.0, and ≥69.1 g ethanol/drinking day were 1.55 (95% CI, 1.01–2.38), and 1.78 (95% CI, 1.02–3.12), respectively. Conclusion: For high drinking frequency per week, more alcohol intake per drinking day was associated with an increased risk of glomerular hyperfiltration, while for low drinking frequency per week, only very high alcohol intake per drinking day was associated with an increased risk of glomerular hyperfiltration in middle-aged Japanese men.https://www.jstage.jst.go.jp/article/jea/34/3/34_JE20220312/_pdfalcoholdrinking patternglomerular hyperfiltrationprospective cohort studyepidemiology |
| spellingShingle | Mikiko Shibata Kyoko Kogawa Sato Hideo Koh Izumi Shibata Kaori Okamura Yuka Takeuchi Keiko Oue Michio Morimoto Tomoshige Hayashi The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study Journal of Epidemiology alcohol drinking pattern glomerular hyperfiltration prospective cohort study epidemiology |
| title | The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study |
| title_full | The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study |
| title_fullStr | The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study |
| title_full_unstemmed | The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study |
| title_short | The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study |
| title_sort | relationship of alcohol consumption and drinking pattern to the risk of glomerular hyperfiltration in middle aged japanese men the kansai healthcare study |
| topic | alcohol drinking pattern glomerular hyperfiltration prospective cohort study epidemiology |
| url | https://www.jstage.jst.go.jp/article/jea/34/3/34_JE20220312/_pdf |
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