Helicobacter pylori Infection, Gastric Cancer and Gastropanel
Gastric cancer (GC) is one of the most widespread types of cancer worldwide. Helicobacter pylori infection has been clearly correlated with gastric carcinogenesis. At present and in the near future, the most important challenge is and will be the significant reduction of mortality due to GC. That go...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Sciendo
2016-09-01
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| Series: | Romanian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rjim-2016-0025 |
| _version_ | 1818468210289147904 |
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| author | Loor Alexandra Dumitraşcu D.L. |
| author_facet | Loor Alexandra Dumitraşcu D.L. |
| author_sort | Loor Alexandra |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most widespread types of cancer worldwide. Helicobacter pylori infection has been clearly correlated with gastric carcinogenesis. At present and in the near future, the most important challenge is and will be the significant reduction of mortality due to GC. That goal can be achieved through the identification of higher-risk patients, such as those with atrophic gastritis, intestinal metaplasia and dysplasia. In this review we intend to discuss the importance of diagnosing H. pylori infection and chronic atrophic gastritis in preventing gastric cancer, using a new non-invasive test called GastroPanel. This test is a classification algorithm including four biochemical parameters pepsinogen I and II (PGI and PGII), gastrin-17 (G17), and anti-Helicobacter pylori antibodies (Ig G anti-Hp) measured in fasting sera, which allows to classify patients as having atrophic or non-atrophic gastritis and to find whether gastritis is associated or not with H. pylori infection. GastroPanel is not a “cancer test”, but it can and should be used in the screening and diagnosis of subjects with a high cancer risk; still, a careful diagnostic made by superior digestive endoscopy is compulsory to find possible precancerous or cancerous lesions at an early and curable stage. |
| first_indexed | 2024-04-13T21:10:13Z |
| format | Article |
| id | doaj.art-535443baf19544c1a04f68824cbbea49 |
| institution | Directory Open Access Journal |
| issn | 2501-062X |
| language | English |
| last_indexed | 2024-04-13T21:10:13Z |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Internal Medicine |
| spelling | doaj.art-535443baf19544c1a04f68824cbbea492022-12-22T02:29:51ZengSciendoRomanian Journal of Internal Medicine2501-062X2016-09-0154315115610.1515/rjim-2016-0025rjim-2016-0025Helicobacter pylori Infection, Gastric Cancer and GastropanelLoor Alexandra0Dumitraşcu D.L.1“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaGastric cancer (GC) is one of the most widespread types of cancer worldwide. Helicobacter pylori infection has been clearly correlated with gastric carcinogenesis. At present and in the near future, the most important challenge is and will be the significant reduction of mortality due to GC. That goal can be achieved through the identification of higher-risk patients, such as those with atrophic gastritis, intestinal metaplasia and dysplasia. In this review we intend to discuss the importance of diagnosing H. pylori infection and chronic atrophic gastritis in preventing gastric cancer, using a new non-invasive test called GastroPanel. This test is a classification algorithm including four biochemical parameters pepsinogen I and II (PGI and PGII), gastrin-17 (G17), and anti-Helicobacter pylori antibodies (Ig G anti-Hp) measured in fasting sera, which allows to classify patients as having atrophic or non-atrophic gastritis and to find whether gastritis is associated or not with H. pylori infection. GastroPanel is not a “cancer test”, but it can and should be used in the screening and diagnosis of subjects with a high cancer risk; still, a careful diagnostic made by superior digestive endoscopy is compulsory to find possible precancerous or cancerous lesions at an early and curable stage.https://doi.org/10.1515/rjim-2016-0025gastric cancerhelicobacter pylorigastropanel |
| spellingShingle | Loor Alexandra Dumitraşcu D.L. Helicobacter pylori Infection, Gastric Cancer and Gastropanel Romanian Journal of Internal Medicine gastric cancer helicobacter pylori gastropanel |
| title | Helicobacter pylori Infection, Gastric Cancer and Gastropanel |
| title_full | Helicobacter pylori Infection, Gastric Cancer and Gastropanel |
| title_fullStr | Helicobacter pylori Infection, Gastric Cancer and Gastropanel |
| title_full_unstemmed | Helicobacter pylori Infection, Gastric Cancer and Gastropanel |
| title_short | Helicobacter pylori Infection, Gastric Cancer and Gastropanel |
| title_sort | helicobacter pylori infection gastric cancer and gastropanel |
| topic | gastric cancer helicobacter pylori gastropanel |
| url | https://doi.org/10.1515/rjim-2016-0025 |
| work_keys_str_mv | AT looralexandra helicobacterpyloriinfectiongastriccancerandgastropanel AT dumitrascudl helicobacterpyloriinfectiongastriccancerandgastropanel |