Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort
Background Evidence suggests that habitual snoring is an independent risk factor for poor glycemic health. We examined the associations between snoring with prediabetes and diabetes in Korean population. Methods Self-reported snoring characteristics were collected from 3,948 middle-aged adults witho...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2020-10-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://www.e-dmj.org/upload/pdf/dmj-2019-0128.pdf |
| _version_ | 1818694566711132160 |
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| author | So Mi Jemma Cho Hokyou Lee Jee-Seon Shim Hyeon Chang Kim |
| author_facet | So Mi Jemma Cho Hokyou Lee Jee-Seon Shim Hyeon Chang Kim |
| author_sort | So Mi Jemma Cho |
| collection | DOAJ |
| description | Background Evidence suggests that habitual snoring is an independent risk factor for poor glycemic health. We examined the associations between snoring with prediabetes and diabetes in Korean population. Methods Self-reported snoring characteristics were collected from 3,948 middle-aged adults without prior cardiovascular diseases. Multivariable linear regression assessed the association of snoring intensity, frequency, disruptiveness, and disrupted breathing with fasting glucose and glycosylated hemoglobin (HbA1c) level. Then, multinomial regression evaluated how increasing snoring symptoms are associated with the risk for prediabetes and diabetes, adjusting for socioeconomic and behavioral risk factors of diabetes, obesity, hypertension, and other sleep variables. Results Higher snoring intensity and frequency were positively associated with fasting glucose and HbA1c levels. Participants presenting the most severe snoring were at 1.84 times higher risk (95% confidence interval [CI], 1.09 to 2.29) for prediabetes and 2.24 times higher risk (95% CI, 1.84 to 2.95) for diabetes, compared to non-snorers. Such graded association was also observed amongst the most frequent snorers with higher risk for prediabetes (odds ratio [OR], 1.78; 95% CI, 1.29 to 2.22) and diabetes (OR, 2.03; 95% CI, 1.45 to 2.85). Disruptive snoring (OR, 1.60; 95% CI, 1.12 to 2.28) and near-daily disruptive breathing (OR, 2.18; 95% CI, 1.02 to 4.19) were associated with higher odds for diabetes. Such findings remained robust after additional adjustment for sleep duration, excessive daytime sleepiness, unwakefulness, and sleep-deprived driving. Conclusion Snoring is associated with impaired glucose metabolism even in otherwise metabolically healthy adults. Habitual snorers may require lifestyle modifications and pharmacological treatment to improve glycemic profile. |
| first_indexed | 2024-12-17T13:31:37Z |
| format | Article |
| id | doaj.art-535550e6f3424e399f0bca0914e2b33f |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-17T13:31:37Z |
| publishDate | 2020-10-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-535550e6f3424e399f0bca0914e2b33f2022-12-21T21:46:33ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872020-10-0144568769810.4093/dmj.2019.01281750Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center CohortSo Mi Jemma Cho0Hokyou Lee1Jee-Seon Shim2Hyeon Chang Kim3Department of Public Health, Yonsei University College of Medicine, Seoul, KoreaDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, KoreaCardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, KoreaDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, KoreaBackground Evidence suggests that habitual snoring is an independent risk factor for poor glycemic health. We examined the associations between snoring with prediabetes and diabetes in Korean population. Methods Self-reported snoring characteristics were collected from 3,948 middle-aged adults without prior cardiovascular diseases. Multivariable linear regression assessed the association of snoring intensity, frequency, disruptiveness, and disrupted breathing with fasting glucose and glycosylated hemoglobin (HbA1c) level. Then, multinomial regression evaluated how increasing snoring symptoms are associated with the risk for prediabetes and diabetes, adjusting for socioeconomic and behavioral risk factors of diabetes, obesity, hypertension, and other sleep variables. Results Higher snoring intensity and frequency were positively associated with fasting glucose and HbA1c levels. Participants presenting the most severe snoring were at 1.84 times higher risk (95% confidence interval [CI], 1.09 to 2.29) for prediabetes and 2.24 times higher risk (95% CI, 1.84 to 2.95) for diabetes, compared to non-snorers. Such graded association was also observed amongst the most frequent snorers with higher risk for prediabetes (odds ratio [OR], 1.78; 95% CI, 1.29 to 2.22) and diabetes (OR, 2.03; 95% CI, 1.45 to 2.85). Disruptive snoring (OR, 1.60; 95% CI, 1.12 to 2.28) and near-daily disruptive breathing (OR, 2.18; 95% CI, 1.02 to 4.19) were associated with higher odds for diabetes. Such findings remained robust after additional adjustment for sleep duration, excessive daytime sleepiness, unwakefulness, and sleep-deprived driving. Conclusion Snoring is associated with impaired glucose metabolism even in otherwise metabolically healthy adults. Habitual snorers may require lifestyle modifications and pharmacological treatment to improve glycemic profile.http://www.e-dmj.org/upload/pdf/dmj-2019-0128.pdfdiabetes mellitus, type 2prediabetic statesnoring |
| spellingShingle | So Mi Jemma Cho Hokyou Lee Jee-Seon Shim Hyeon Chang Kim Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort Diabetes & Metabolism Journal diabetes mellitus, type 2 prediabetic state snoring |
| title | Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort |
| title_full | Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort |
| title_fullStr | Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort |
| title_full_unstemmed | Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort |
| title_short | Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort |
| title_sort | association of snoring with prediabetes and type 2 diabetes mellitus the cardiovascular and metabolic diseases etiology research center cohort |
| topic | diabetes mellitus, type 2 prediabetic state snoring |
| url | http://www.e-dmj.org/upload/pdf/dmj-2019-0128.pdf |
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