Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages?
Antimicrobial resistance is a major threat to human and animal health and accounted for up to 4.5 million deaths worldwide in 2019. Asymptomatic colonization of the digestive tract by multidrug resistant (multi-resistant) bacteria such as extended-spectrum beta-lactamase-, or carbapenemase- producin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1266416/full |
| _version_ | 1797503305834823680 |
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| author | Mehdi Bonnet Catherine Eckert Catherine Eckert Catherine Eckert Régis Tournebize Régis Tournebize Régis Tournebize |
| author_facet | Mehdi Bonnet Catherine Eckert Catherine Eckert Catherine Eckert Régis Tournebize Régis Tournebize Régis Tournebize |
| author_sort | Mehdi Bonnet |
| collection | DOAJ |
| description | Antimicrobial resistance is a major threat to human and animal health and accounted for up to 4.5 million deaths worldwide in 2019. Asymptomatic colonization of the digestive tract by multidrug resistant (multi-resistant) bacteria such as extended-spectrum beta-lactamase-, or carbapenemase- producing Enterobacterales is (i) a risk factor for infection by these multi-resistant bacteria, (ii) a risk factor of dissemination of these multi-resistant bacteria among patients and in the community, and (iii) allows the exchange of resistance genes between bacteria. Hence, decolonization or reduction of the gastrointestinal tract colonization of these multi-resistant bacteria needs to be urgently explored. Developing new non-antibiotic strategies to limit or eradicate multi-resistant bacteria carriage without globally disrupting the microbiota is considered a priority to fight against antibiotic resistance. Probiotics or Fecal Microbiota Transplantation are alternative strategies to antibiotics that have been considered to decolonize intestinal tract from MDR bacteria but there is currently no evidence demonstrating their efficacy. Lytic bacteriophages are viruses that kill bacteria and therefore could be considered as a promising strategy to combat antibiotic resistance. Successful decolonization by bacteriophages has already been observed clinically. Here, we discuss the current alternative strategies considered to decolonize the digestive tract of multidrug resistant bacteria, briefly describing probiotics and fecal microbiota transplantation approaches, and then detail the in vivo and in vitro studies using bacteriophages, while discussing their limits regarding the animal models used, the characteristics of phages used and their activity in regards of the gut anatomy. |
| first_indexed | 2024-03-10T03:48:41Z |
| format | Article |
| id | doaj.art-53555656c37a48f2adb6a719a8d568a2 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-10T03:48:41Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-53555656c37a48f2adb6a719a8d568a22023-11-23T09:01:19ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-11-011410.3389/fmicb.2023.12664161266416Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages?Mehdi Bonnet0Catherine Eckert1Catherine Eckert2Catherine Eckert3Régis Tournebize4Régis Tournebize5Régis Tournebize6Département de Bactériologie, Hôpital Saint-Antoine, AP-HP, Sorbonne Université, Paris, FranceDépartement de Bactériologie, Hôpital Saint-Antoine, AP-HP, Sorbonne Université, Paris, FranceCentre d'Immunologie et des Maladies Infectieuses, INSERM, U1135, Sorbonne Université, Paris, FranceParis Centre for Microbiome Medicine (PaCeMM) FHU, Paris, FranceCentre d'Immunologie et des Maladies Infectieuses, INSERM, U1135, Sorbonne Université, Paris, FranceParis Centre for Microbiome Medicine (PaCeMM) FHU, Paris, FranceInstitut Pasteur, Université Paris Cité, Photonic Bio-Imaging, Centre de Ressources et Recherches Technologiques (UTechS-PBI, C2RT), Paris, FranceAntimicrobial resistance is a major threat to human and animal health and accounted for up to 4.5 million deaths worldwide in 2019. Asymptomatic colonization of the digestive tract by multidrug resistant (multi-resistant) bacteria such as extended-spectrum beta-lactamase-, or carbapenemase- producing Enterobacterales is (i) a risk factor for infection by these multi-resistant bacteria, (ii) a risk factor of dissemination of these multi-resistant bacteria among patients and in the community, and (iii) allows the exchange of resistance genes between bacteria. Hence, decolonization or reduction of the gastrointestinal tract colonization of these multi-resistant bacteria needs to be urgently explored. Developing new non-antibiotic strategies to limit or eradicate multi-resistant bacteria carriage without globally disrupting the microbiota is considered a priority to fight against antibiotic resistance. Probiotics or Fecal Microbiota Transplantation are alternative strategies to antibiotics that have been considered to decolonize intestinal tract from MDR bacteria but there is currently no evidence demonstrating their efficacy. Lytic bacteriophages are viruses that kill bacteria and therefore could be considered as a promising strategy to combat antibiotic resistance. Successful decolonization by bacteriophages has already been observed clinically. Here, we discuss the current alternative strategies considered to decolonize the digestive tract of multidrug resistant bacteria, briefly describing probiotics and fecal microbiota transplantation approaches, and then detail the in vivo and in vitro studies using bacteriophages, while discussing their limits regarding the animal models used, the characteristics of phages used and their activity in regards of the gut anatomy.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1266416/fulldecolonizationmicrobiotabacteriophagemultidrug resistant bacteriaEnterobacterales |
| spellingShingle | Mehdi Bonnet Catherine Eckert Catherine Eckert Catherine Eckert Régis Tournebize Régis Tournebize Régis Tournebize Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages? Frontiers in Microbiology decolonization microbiota bacteriophage multidrug resistant bacteria Enterobacterales |
| title | Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages? |
| title_full | Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages? |
| title_fullStr | Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages? |
| title_full_unstemmed | Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages? |
| title_short | Decolonization of asymptomatic carriage of multi-drug resistant bacteria by bacteriophages? |
| title_sort | decolonization of asymptomatic carriage of multi drug resistant bacteria by bacteriophages |
| topic | decolonization microbiota bacteriophage multidrug resistant bacteria Enterobacterales |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1266416/full |
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