Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth
Abstract Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-04-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-01932-5 |
| _version_ | 1797219996912320512 |
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| author | Natsuki Furukawa Wendy Yang Alex R. Chao Akash Patil Adam C. Mirando Niranjan B. Pandey Aleksander S. Popel |
| author_facet | Natsuki Furukawa Wendy Yang Alex R. Chao Akash Patil Adam C. Mirando Niranjan B. Pandey Aleksander S. Popel |
| author_sort | Natsuki Furukawa |
| collection | DOAJ |
| description | Abstract Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer. |
| first_indexed | 2024-04-24T12:42:31Z |
| format | Article |
| id | doaj.art-535565cc213d4f06a93b1286166d686d |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-24T12:42:31Z |
| publishDate | 2024-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-535565cc213d4f06a93b1286166d686d2024-04-07T11:08:33ZengNature Publishing GroupCell Death Discovery2058-77162024-04-0110111110.1038/s41420-024-01932-5Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growthNatsuki Furukawa0Wendy Yang1Alex R. Chao2Akash Patil3Adam C. Mirando4Niranjan B. Pandey5Aleksander S. Popel6Department of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineAbstract Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer.https://doi.org/10.1038/s41420-024-01932-5 |
| spellingShingle | Natsuki Furukawa Wendy Yang Alex R. Chao Akash Patil Adam C. Mirando Niranjan B. Pandey Aleksander S. Popel Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth Cell Death Discovery |
| title | Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth |
| title_full | Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth |
| title_fullStr | Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth |
| title_full_unstemmed | Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth |
| title_short | Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth |
| title_sort | chemokine derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth |
| url | https://doi.org/10.1038/s41420-024-01932-5 |
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