Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors?
Experience shapes and molds the brain throughout life. These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00049/full |
| _version_ | 1818196133123457024 |
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| author | Jason D Shepherd |
| author_facet | Jason D Shepherd |
| author_sort | Jason D Shepherd |
| collection | DOAJ |
| description | Experience shapes and molds the brain throughout life. These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor, is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity. These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target. |
| first_indexed | 2024-12-12T01:29:14Z |
| format | Article |
| id | doaj.art-53569bcca9524386acf8e01b1e35d90a |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-12T01:29:14Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-53569bcca9524386acf8e01b1e35d90a2022-12-22T00:43:01ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992012-04-01510.3389/fnmol.2012.0004915048Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors?Jason D Shepherd0Massachusetts Institute of TechnologyExperience shapes and molds the brain throughout life. These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor, is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity. These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target.http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00049/fullMemorySleepFear conditioninghomeostatic plasticitysynaptic plasticitydrug addiction |
| spellingShingle | Jason D Shepherd Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors? Frontiers in Molecular Neuroscience Memory Sleep Fear conditioning homeostatic plasticity synaptic plasticity drug addiction |
| title | Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors? |
| title_full | Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors? |
| title_fullStr | Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors? |
| title_full_unstemmed | Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors? |
| title_short | Memory, Plasticity and Sleep - A role for calcium permeable AMPA receptors? |
| title_sort | memory plasticity and sleep a role for calcium permeable ampa receptors |
| topic | Memory Sleep Fear conditioning homeostatic plasticity synaptic plasticity drug addiction |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00049/full |
| work_keys_str_mv | AT jasondshepherd memoryplasticityandsleeparoleforcalciumpermeableampareceptors |