Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial
Abstract Zinc deficiency impairs the antibody-mediated immune response and is common in children from lower-income countries. This study aimed to investigate the impact of different zinc supplementation regimens (7, 10 or 20 mg/day elemental zinc)—therapeutic dispersible zinc tablets (TZ), daily mul...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20445-8 |
| _version_ | 1797998311145209856 |
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| author | Chidchamai Kewcharoenwong Myint Myint Sein Arnone Nithichanon Aranya Khongmee K Ryan Wessells Guy-Marino Hinnouho Maxwell A. Barffour Sengchanh Kounnavong Sonja Y. Hess Charles B. Stephensen Ganjana Lertmemongkolchai |
| author_facet | Chidchamai Kewcharoenwong Myint Myint Sein Arnone Nithichanon Aranya Khongmee K Ryan Wessells Guy-Marino Hinnouho Maxwell A. Barffour Sengchanh Kounnavong Sonja Y. Hess Charles B. Stephensen Ganjana Lertmemongkolchai |
| author_sort | Chidchamai Kewcharoenwong |
| collection | DOAJ |
| description | Abstract Zinc deficiency impairs the antibody-mediated immune response and is common in children from lower-income countries. This study aimed to investigate the impact of different zinc supplementation regimens (7, 10 or 20 mg/day elemental zinc)—therapeutic dispersible zinc tablets (TZ), daily multiple micronutrient powder (MNP), daily preventive zinc tablets (PZ) and placebo powder (control)—and compare between baseline and endline antibody production against pathogenic Escherichia coli in Laotian children (aged 6–23 months). Fifty representative plasma samples of each treatment group were randomly selected from 512 children to determine anti-E. coli IgG antibody levels and avidity. Of the 200 children, 78.5% had zinc deficiency (plasma zinc concentration < 65 µg/dL) and 40% had anaemia before receiving zinc supplementation. aAfter receiving the TZ, MNP or PZ regimen, the plasma anti-E. coli IgG levels were significantly increased compared with baseline; the effect on the antibody level was more pronounced in children with zinc deficiency. Interestingly, there was increased anti-E. coli IgG avidity in the control and PZ groups. This study suggests that PZ might be the optimal zinc supplementation regimen to increase both the quantity and quality of antibody responses in children with zinc deficiency. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT02428647 (NCT02428647, 29/04/2015). |
| first_indexed | 2024-04-11T10:46:41Z |
| format | Article |
| id | doaj.art-5358286860e94ce9884e97e791bca949 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T10:46:41Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5358286860e94ce9884e97e791bca9492022-12-22T04:29:01ZengNature PortfolioScientific Reports2045-23222022-09-011211910.1038/s41598-022-20445-8Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trialChidchamai Kewcharoenwong0Myint Myint Sein1Arnone Nithichanon2Aranya Khongmee3K Ryan Wessells4Guy-Marino Hinnouho5Maxwell A. Barffour6Sengchanh Kounnavong7Sonja Y. Hess8Charles B. Stephensen9Ganjana Lertmemongkolchai10Faculty of Associated Medical Sciences, Chiang Mai UniversityThe Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen UniversityDepartment of Microbiology, Faculty of Medicine, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen UniversityThe Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen UniversityDepartment of Nutrition, Institute for Global Nutrition, University of CaliforniaDepartment of Nutrition, Institute for Global Nutrition, University of CaliforniaDepartment of Nutrition, Institute for Global Nutrition, University of CaliforniaLao Tropical and Public Health InstituteDepartment of Nutrition, Institute for Global Nutrition, University of CaliforniaDepartment of Nutrition, Institute for Global Nutrition, University of CaliforniaFaculty of Associated Medical Sciences, Chiang Mai UniversityAbstract Zinc deficiency impairs the antibody-mediated immune response and is common in children from lower-income countries. This study aimed to investigate the impact of different zinc supplementation regimens (7, 10 or 20 mg/day elemental zinc)—therapeutic dispersible zinc tablets (TZ), daily multiple micronutrient powder (MNP), daily preventive zinc tablets (PZ) and placebo powder (control)—and compare between baseline and endline antibody production against pathogenic Escherichia coli in Laotian children (aged 6–23 months). Fifty representative plasma samples of each treatment group were randomly selected from 512 children to determine anti-E. coli IgG antibody levels and avidity. Of the 200 children, 78.5% had zinc deficiency (plasma zinc concentration < 65 µg/dL) and 40% had anaemia before receiving zinc supplementation. aAfter receiving the TZ, MNP or PZ regimen, the plasma anti-E. coli IgG levels were significantly increased compared with baseline; the effect on the antibody level was more pronounced in children with zinc deficiency. Interestingly, there was increased anti-E. coli IgG avidity in the control and PZ groups. This study suggests that PZ might be the optimal zinc supplementation regimen to increase both the quantity and quality of antibody responses in children with zinc deficiency. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT02428647 (NCT02428647, 29/04/2015).https://doi.org/10.1038/s41598-022-20445-8 |
| spellingShingle | Chidchamai Kewcharoenwong Myint Myint Sein Arnone Nithichanon Aranya Khongmee K Ryan Wessells Guy-Marino Hinnouho Maxwell A. Barffour Sengchanh Kounnavong Sonja Y. Hess Charles B. Stephensen Ganjana Lertmemongkolchai Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial Scientific Reports |
| title | Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial |
| title_full | Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial |
| title_fullStr | Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial |
| title_full_unstemmed | Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial |
| title_short | Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial |
| title_sort | daily preventive zinc supplementation increases the antibody response against pathogenic escherichia coli in children with zinc insufficiency a randomised controlled trial |
| url | https://doi.org/10.1038/s41598-022-20445-8 |
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