Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation
This review article presents data about the influence of deuterium-depleted water (DDW) on biological systems. It is known that the isotope abundances of natural and bottled waters are variable worldwide. That is why different drinking rations lead to changes of stable isotopes content in body water...
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MDPI AG
2019-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/11/8/1903 |
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| author | Alexander Basov Liliia Fedulova Mikhail Baryshev Stepan Dzhimak |
| author_facet | Alexander Basov Liliia Fedulova Mikhail Baryshev Stepan Dzhimak |
| author_sort | Alexander Basov |
| collection | DOAJ |
| description | This review article presents data about the influence of deuterium-depleted water (DDW) on biological systems. It is known that the isotope abundances of natural and bottled waters are variable worldwide. That is why different drinking rations lead to changes of stable isotopes content in body water fluxes in human and animal organisms. Also, intracellular water isotope ratios in living systems depends on metabolic activity and food consumption. We found the <sup>2</sup>H/<sup>1</sup>H gradient in human fluids (δ<sup>2</sup>H <sub>saliva</sub> >> δ<sup>2</sup>H <sub>blood plasma</sub> > δ<sup>2</sup>H<sub>breast milk</sub>), which decreases significantly during DDW intake. Moreover, DDW induces several important biological effects in organism (antioxidant, metabolic detoxification, anticancer, rejuvenation, behavior, etc.). Changing the isotope <sup>2</sup>H/<sup>1</sup>H gradient from “<sup>2</sup>H <sub>blood plasma</sub> > δ<sup>2</sup>H <sub>visceral organs</sub>” to “δ<sup>2</sup>H <sub>blood plasma</sub> << δ<sup>2</sup>H <sub>visceral organs</sub>” via DDW drinking increases individual adaptation by isotopic shock. The other possible mechanisms of long-term adaptation is DDW influence on the growth rate of cells, enzyme activity and cellular energetics (e.g., stimulation of the mitochondrion activity). In addition, DDW reduces the number of single-stranded DNA breaks and modifies the miRNA profile. |
| first_indexed | 2024-04-12T08:16:30Z |
| format | Article |
| id | doaj.art-535919a0ed7846be9262545ed3d7e144 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-12T08:16:30Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-535919a0ed7846be9262545ed3d7e1442022-12-22T03:40:46ZengMDPI AGNutrients2072-66432019-08-01118190310.3390/nu11081903nu11081903Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual AdaptationAlexander Basov0Liliia Fedulova1Mikhail Baryshev2Stepan Dzhimak3Kuban State Medical University, 350063 Krasnodar, RussiaThe V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, 109316 Moscow, RussiaKuban State University, 350040 Krasnodar, RussiaKuban State University, 350040 Krasnodar, RussiaThis review article presents data about the influence of deuterium-depleted water (DDW) on biological systems. It is known that the isotope abundances of natural and bottled waters are variable worldwide. That is why different drinking rations lead to changes of stable isotopes content in body water fluxes in human and animal organisms. Also, intracellular water isotope ratios in living systems depends on metabolic activity and food consumption. We found the <sup>2</sup>H/<sup>1</sup>H gradient in human fluids (δ<sup>2</sup>H <sub>saliva</sub> >> δ<sup>2</sup>H <sub>blood plasma</sub> > δ<sup>2</sup>H<sub>breast milk</sub>), which decreases significantly during DDW intake. Moreover, DDW induces several important biological effects in organism (antioxidant, metabolic detoxification, anticancer, rejuvenation, behavior, etc.). Changing the isotope <sup>2</sup>H/<sup>1</sup>H gradient from “<sup>2</sup>H <sub>blood plasma</sub> > δ<sup>2</sup>H <sub>visceral organs</sub>” to “δ<sup>2</sup>H <sub>blood plasma</sub> << δ<sup>2</sup>H <sub>visceral organs</sub>” via DDW drinking increases individual adaptation by isotopic shock. The other possible mechanisms of long-term adaptation is DDW influence on the growth rate of cells, enzyme activity and cellular energetics (e.g., stimulation of the mitochondrion activity). In addition, DDW reduces the number of single-stranded DNA breaks and modifies the miRNA profile.https://www.mdpi.com/2072-6643/11/8/1903deuteriumwateradaptationDNA |
| spellingShingle | Alexander Basov Liliia Fedulova Mikhail Baryshev Stepan Dzhimak Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation Nutrients deuterium water adaptation DNA |
| title | Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation |
| title_full | Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation |
| title_fullStr | Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation |
| title_full_unstemmed | Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation |
| title_short | Deuterium-Depleted Water Influence on the Isotope <sup>2</sup>H/<sup>1</sup>H Regulation in Body and Individual Adaptation |
| title_sort | deuterium depleted water influence on the isotope sup 2 sup h sup 1 sup h regulation in body and individual adaptation |
| topic | deuterium water adaptation DNA |
| url | https://www.mdpi.com/2072-6643/11/8/1903 |
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