ER+, HER2− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

ER+, HER2− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

Taselisib is a potent β‐sparing phosphatidylinositol 3‐kinase (PI3K) inhibitor that, with endocrine therapy, improves outcomes in phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA)‐mutated (PIK3CAmut) advanced breast cancer. To understand alterations associated with resp...

Full description

Bibliographic Details
Main Authors:	Jessica W. Chen, William Jacot, Javier Cortés, Ian E. Krop, Susan Dent, Nadia Harbeck, Michelino De Laurentiis, Véronique Diéras, Young‐Hyuck Im, Thomas J. Stout, Frauke Schimmoller, Heidi M. Savage, Katherine E. Hutchinson, Timothy R. Wilson
Format:	Article
Language:	English
Published:	Wiley 2023-10-01
Series:	Molecular Oncology
Subjects:	breast cancer circulating tumour DNA PIK3CA SANDPIPER taselisib
Online Access:	https://doi.org/10.1002/1878-0261.13416

Similar Items

Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers
by: Katherine E. Hutchinson, et al.
Published: (2023-04-01)

The Influence of Body Condition on the Stopover Ecology of Least Sandpipers in the Lower Mississippi Alluvial Valley during Fall Migration
by: Sarah E. Lehnen, et al.
Published: (2007-12-01)

Mitochondrial genome analysis of the spoon-billed sandpiper (Eurynorhynchus pygmeus)
by: Hey-Sook Joen, et al.
Published: (2017-01-01)

[Sightings of Purple Sandpiper Calidris maritima in Italy, a review]
by: Maurizio Sighele
Published: (2018-12-01)

Target therapy of luminal HER2-negative advanced breast cancer with PIK3CA mutation: combination of alpelisib plus fulvestrant in real clinical practice
by: D. A. Filonenko, et al.
Published: (2021-12-01)

Automated VHF Radiotelemetry Revealed Site-Specific Differences in Fall Migration Strategies of Semipalmated Sandpipers on Stopover in the Gulf of Maine
by: Rebecca L. Holberton, et al.
Published: (2019-09-01)

Feather mites of Calidris fuscicollis (Aves: Scolopacidae) in Brazil
by: S. N. Gomes, et al.

Migration of Common Sandpiper Actitis hypoleucos L. (Aves: Charadriiformes) in the Cholgini ornithological reserve
by: Iu. M. Strus, et al.
Published: (2013-09-01)

Avian wings can lengthen rather than shorten in response to increased migratory predation danger
by: Ronald C. Ydenberg, et al.
Published: (2023-07-01)

First record of the Buff-breasted Sandpiper Tryngites subruficollis (Aves: Scolopacidae) in Santa Catarina state and an additional record for Paraná state, southern Brazil
by: Marcos Ricardo Bornschein, et al.
Published: (2010-06-01)

PIK3CA, KI67, Estrogen (ER) and Progesterone Receptors (PR) Expression Pattern of in HER2 Positive Breast Cancers
by: Samuel I. Ogenyi, et al.
Published: (2022-02-01)

Food resources for Spoon-billed Sandpipers (Calidris pygmaea) in the mudflats of Leizhou Bay, southern China
by: Xiuyuan Lu, et al.
Published: (2022-09-01)

Distribution Modeling and Gap Analysis of Shorebird Conservation in Northern Brazil
by: Daniel Merchant, et al.
Published: (2023-01-01)

Migrant Semipalmated Sandpipers (Calidris pusilla) Have Over Four Decades Steadily Shifted Towards Safer Stopover Locations
by: David D. Hope, et al.
Published: (2020-01-01)

Phase II trial of fulvestrant plus enzalutamide in ER+/HER2− advanced breast cancer
by: Anthony D. Elias, et al.
Published: (2023-05-01)

Promising Therapeutic Impact of a Selective Estrogen Receptor Downregulator, Fulvestrant, as Demonstrated In Vitro upon Low-Grade Serous Ovarian Carcinoma Cell Lines
by: Kamrunnahar Shanta, et al.
Published: (2022-06-01)

Results of multicenter testing of PIK3CA somatic mutations in hormone-receptor positive HER2-negative advanced breast cancer
by: Snježana Ramić, et al.
Published: (2023-01-01)

Length of stay and departure strategies of Semipalmated Sandpipers (Calidris pusilla) during post-breeding migration in the upper Bay of Fundy, Canada
by: Sarah G. Neima, et al.
Published: (2022-09-01)

Site Safety and Food Affect Movements of Semipalmated Sandpipers (Calidris pusilla) Migrating Through the Upper Bay of Fundy
by: Ashley J. Sprague, et al.
Published: (2008-12-01)

Assessing conservation conflict: Does intertidal oyster aquaculture inhibit foraging behavior of migratory shorebirds?
by: Brooke Maslo, et al.
Published: (2020-05-01)

Mercury, Lead, Cadmium, Cobalt, Arsenic and Selenium in the Blood of Semipalmated Sandpipers (Calidris pusilla) from Suriname, South America: Age-related Differences in Wintering Site and Comparisons with a Stopover Site in New Jersey, USA
by: Joanna Burger, et al.
Published: (2018-05-01)

Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project
by: Ana Peixoto, et al.
Published: (2023-02-01)

Sandpiper Optimization Algorithm With Region Growing Based Robust Retinal Blood Vessel Segmentation Approach
by: Ibrahim AlMohimeed, et al.
Published: (2024-01-01)

Variation in resource use between adult and juvenile Semipalmated Sandpipers (Calidris pusilla) and use of physiological indicators for movement decisions highlights the importance of small staging sites during southbound migration in Atlantic Canada
by: Rebeca C. Linhart, et al.
Published: (2022-12-01)

The consensus on the prevention and correction of rash in patients with HR+ HER2- metastatic breast cancer treated with alpelisib
by: Irena L. Shlivko, et al.
Published: (2021-12-01)

The consensus on the prevention and correction of hyperglycemia in patients with HR+ HER2- metastatic breast cancer treated with alpelisib
by: Natalya V. Mazurina, et al.
Published: (2021-02-01)

Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
by: Jill M. Spoerke, et al.
Published: (2016-05-01)

Analisis perkembangan pusat informasi dan konseling remaja di Sekolah Menegah Atas Negeri 3 Bantul DIY
by: Dwi Fujiastuti
Published: (2018-12-01)

Clinical profile of overgrowth syndromes consistent with PROS (PIK3CA-related overgrowth syndromes)—A case series
by: Lydia Mathew, et al.
Published: (2020-01-01)

Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: from next-generation sequencing to clinical significance
by: Yeh YM, et al.
Published: (2019-08-01)

Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer
by: Edith A. Perez, et al.
Published: (2019-05-01)

Intra- and interannual regional fidelity of Semipalmated Sandpipers (Calidris pusilla) during migratory stopover in the upper Bay of Fundy, Canada
by: Sarah G. Neima, et al.
Published: (2020-06-01)

The effect of the alpha-specific PI3K inhibitor alpelisib combined with anti-HER2 therapy in HER2+/PIK3CA mutant breast cancer
by: Maria Letizia Cataldo, et al.
Published: (2023-07-01)

Metodološki pristup optimalizaciji poslovanja PIK "Belje”
by: Ivan Mecanović
Published: (1990-01-01)

Role of Adolescents’ Reproductive Health Information and Counselling Program towards Knowledge and Attitude in Pregnancy Planning among Adolescent Female in Malang City
by: Dini Eka Pripuspitasari, et al.
Published: (2018-11-01)

Pembentukkan Pusat Informasi dan Konseling Kesehatan Reproduksi Remaja (PIK-KRR) di SMPN 28 Kota Pekanbaru
by: Yanti, et al.
Published: (2021-12-01)

EFEKTIVITAS PROGRAM GENERASI BERENCANA PUSAT INFORMASI KONSELING (PIK) REMAJA BAGI SISWA SMA NEGERI DI KOTA BANDA ACEH
by: Intan Liana
Published: (2018-11-01)

Pengembangan Sistem Pengelolaan Informasi Pusat Informasi dan Konseling Remaja Kota Padang
by: Isra Wilna, et al.
Published: (2017-04-01)

Profiling PIK3CA variants in disorders of somatic mosaicism
by: Bahareh A. Mojarad, et al.
Published: (2023-01-01)

Screening thepresence of avirulence genes from blast fungal isolates, Magnaporthe oryzae, in Vietnam.
by: Nguyễn Bằng Phương, et al.
Published: (2017-12-01)