The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies
Neurological disorders such as neurodegenerative diseases or traumatic brain injury are associated with cognitive, motor and behavioural changes that influence the quality of life of the patients. Although different therapeutic strategies have been developed and tried until now to decrease the neuro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/8/2395 |
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| author | Daniela Calina Ana Maria Buga Mihaela Mitroi Aleksandra Buha Constantin Caruntu Cristian Scheau Abdelhakim Bouyahya Nasreddine El Omari Naoual El Menyiy Anca Oana Docea |
| author_facet | Daniela Calina Ana Maria Buga Mihaela Mitroi Aleksandra Buha Constantin Caruntu Cristian Scheau Abdelhakim Bouyahya Nasreddine El Omari Naoual El Menyiy Anca Oana Docea |
| author_sort | Daniela Calina |
| collection | DOAJ |
| description | Neurological disorders such as neurodegenerative diseases or traumatic brain injury are associated with cognitive, motor and behavioural changes that influence the quality of life of the patients. Although different therapeutic strategies have been developed and tried until now to decrease the neurological decline, no treatment has been found to cure these pathologies. In the last decades, the implication of the endocannabinoid system in the neurological function has been extensively studied, and the cannabinoids have been tried as a new promising potential treatment. In this study, we aimed to overview the recent available literature regarding in vivo potential of natural and synthetic cannabinoids with underlying mechanisms of action for protecting against cognitive decline and motor impairments. The results of studies on animal models showed that cannabinoids in traumatic brain injury increase neurobehavioral function, working memory performance, and decrease the neurological deficit and ameliorate motor deficit through down-regulation of pro-inflammatory markers, oedema formation and blood–brain barrier permeability, preventing neuronal cell loss and up-regulating the levels of adherence junction proteins. In neurodegenerative diseases, the cannabinoids showed beneficial effects in decreasing the motor disability and disease progression by a complex mechanism targeting more signalling pathways further than classical receptors of the endocannabinoid system. In light of these results, the use of cannabinoids could be beneficial in traumatic brain injuries and multiple sclerosis treatment, especially in those patients who display resistance to conventional treatment. |
| first_indexed | 2024-03-10T18:11:02Z |
| format | Article |
| id | doaj.art-535a7f55111d4106a1498ea523729f0c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:11:02Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-535a7f55111d4106a1498ea523729f0c2023-11-20T08:04:57ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0198239510.3390/jcm9082395The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo StudiesDaniela Calina0Ana Maria Buga1Mihaela Mitroi2Aleksandra Buha3Constantin Caruntu4Cristian Scheau5Abdelhakim Bouyahya6Nasreddine El Omari7Naoual El Menyiy8Anca Oana Docea9Clinical Pharmacy Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaBiochemistry Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaENT Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Toxicology “Akademik Danilo Soldatović”-Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, SerbiaDepartment of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, 10106 Rabat, MoroccoLaboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, 10100 Rabat, MoroccoLaboratory of Physiology, Pharmacology & Environmental Health, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, 30000 Fez, MoroccoToxicology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaNeurological disorders such as neurodegenerative diseases or traumatic brain injury are associated with cognitive, motor and behavioural changes that influence the quality of life of the patients. Although different therapeutic strategies have been developed and tried until now to decrease the neurological decline, no treatment has been found to cure these pathologies. In the last decades, the implication of the endocannabinoid system in the neurological function has been extensively studied, and the cannabinoids have been tried as a new promising potential treatment. In this study, we aimed to overview the recent available literature regarding in vivo potential of natural and synthetic cannabinoids with underlying mechanisms of action for protecting against cognitive decline and motor impairments. The results of studies on animal models showed that cannabinoids in traumatic brain injury increase neurobehavioral function, working memory performance, and decrease the neurological deficit and ameliorate motor deficit through down-regulation of pro-inflammatory markers, oedema formation and blood–brain barrier permeability, preventing neuronal cell loss and up-regulating the levels of adherence junction proteins. In neurodegenerative diseases, the cannabinoids showed beneficial effects in decreasing the motor disability and disease progression by a complex mechanism targeting more signalling pathways further than classical receptors of the endocannabinoid system. In light of these results, the use of cannabinoids could be beneficial in traumatic brain injuries and multiple sclerosis treatment, especially in those patients who display resistance to conventional treatment.https://www.mdpi.com/2077-0383/9/8/2395cannabinoidsbrain injuryneurodegenerative disordersanimal modelsmolecular mechanisms |
| spellingShingle | Daniela Calina Ana Maria Buga Mihaela Mitroi Aleksandra Buha Constantin Caruntu Cristian Scheau Abdelhakim Bouyahya Nasreddine El Omari Naoual El Menyiy Anca Oana Docea The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies Journal of Clinical Medicine cannabinoids brain injury neurodegenerative disorders animal models molecular mechanisms |
| title | The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies |
| title_full | The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies |
| title_fullStr | The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies |
| title_full_unstemmed | The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies |
| title_short | The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies |
| title_sort | treatment of cognitive behavioural and motor impairments from brain injury and neurodegenerative diseases through cannabinoid system modulation evidence from in vivo studies |
| topic | cannabinoids brain injury neurodegenerative disorders animal models molecular mechanisms |
| url | https://www.mdpi.com/2077-0383/9/8/2395 |
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