The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial
Yazhuo Li, Dewu Zhang, Bing Hang, Hao Wang Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an, People’s Republic of ChinaCorrespondence: Hao Wang, Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University (Xibei...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-12-01
|
| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-efficacy-of-combination-therapy-involving-excision-followed-by-int-peer-reviewed-fulltext-article-CCID |
| _version_ | 1797975934576361472 |
|---|---|
| author | Li Y Zhang D Hang B Wang H |
| author_facet | Li Y Zhang D Hang B Wang H |
| author_sort | Li Y |
| collection | DOAJ |
| description | Yazhuo Li, Dewu Zhang, Bing Hang, Hao Wang Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an, People’s Republic of ChinaCorrespondence: Hao Wang, Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), No. 157, West 5th Road, Xi’an, Shaanxi Province, 710004, People’s Republic of China, Tel +86 182 9183 9156, Email wanghaonxyc@xjtu.edu.cnBackground: Combined therapy for keloids is currently recommended. Surgery is one of the main options, but the measures to prevent recurrence after excision are still being explored.Objective: The randomized controlled study aimed at evaluating the efficacy of excision followed by intralesional low concentrations of 5-fluorouracil (5-FU)(12.5 mg/mL) and betamethasone.Methods: Sixty patients were randomly assigned to three groups. Patients in group A had excision followed by 5-FU and betamethasone intralesional injections, group B had 5-FU and betamethasone intralesional injections, and group C had excision followed by radiotherapy. Efficacy parameters were assessed from 8 to 12 months, including improvement on the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Scale (POSAS), as well as side effects and recurrence. Trial registration number: ChiCTR2100046025.Results: After 4 months’ treatment, the improvement of the VSS and POSAS scores in group A was not different from that in group C (P > 0.05) but was superior to that in group B (P < 0.05); the pain and pruritus of the three groups were relieved more than 50%. After 8 to 12 months’ follow-up, there was no statistical difference in the incidence of side effects and recurrence among the groups (P > 0.05).Conclusion: Excision followed by intralesional low concentrations of 5-FU (12.5mg/mL) with betamethasone is a safe and sustainable treatment for keloid, with no significant difference from excision followed by radiotherapy.Keywords: keloid, excision, 5-fluorouracil, betamethasone, radiotherapy |
| first_indexed | 2024-04-11T04:43:19Z |
| format | Article |
| id | doaj.art-535e4f96ff4a48b69aa6d270b18072dd |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-04-11T04:43:19Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-535e4f96ff4a48b69aa6d270b18072dd2022-12-27T17:34:40ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-12-01Volume 152845285480587The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled TrialLi YZhang DHang BWang HYazhuo Li, Dewu Zhang, Bing Hang, Hao Wang Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an, People’s Republic of ChinaCorrespondence: Hao Wang, Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), No. 157, West 5th Road, Xi’an, Shaanxi Province, 710004, People’s Republic of China, Tel +86 182 9183 9156, Email wanghaonxyc@xjtu.edu.cnBackground: Combined therapy for keloids is currently recommended. Surgery is one of the main options, but the measures to prevent recurrence after excision are still being explored.Objective: The randomized controlled study aimed at evaluating the efficacy of excision followed by intralesional low concentrations of 5-fluorouracil (5-FU)(12.5 mg/mL) and betamethasone.Methods: Sixty patients were randomly assigned to three groups. Patients in group A had excision followed by 5-FU and betamethasone intralesional injections, group B had 5-FU and betamethasone intralesional injections, and group C had excision followed by radiotherapy. Efficacy parameters were assessed from 8 to 12 months, including improvement on the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Scale (POSAS), as well as side effects and recurrence. Trial registration number: ChiCTR2100046025.Results: After 4 months’ treatment, the improvement of the VSS and POSAS scores in group A was not different from that in group C (P > 0.05) but was superior to that in group B (P < 0.05); the pain and pruritus of the three groups were relieved more than 50%. After 8 to 12 months’ follow-up, there was no statistical difference in the incidence of side effects and recurrence among the groups (P > 0.05).Conclusion: Excision followed by intralesional low concentrations of 5-FU (12.5mg/mL) with betamethasone is a safe and sustainable treatment for keloid, with no significant difference from excision followed by radiotherapy.Keywords: keloid, excision, 5-fluorouracil, betamethasone, radiotherapyhttps://www.dovepress.com/the-efficacy-of-combination-therapy-involving-excision-followed-by-int-peer-reviewed-fulltext-article-CCIDkeloidexcision5-fluorouracilbetamethasoneradiotherapy |
| spellingShingle | Li Y Zhang D Hang B Wang H The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial Clinical, Cosmetic and Investigational Dermatology keloid excision 5-fluorouracil betamethasone radiotherapy |
| title | The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial |
| title_full | The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial |
| title_fullStr | The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial |
| title_full_unstemmed | The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial |
| title_short | The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial |
| title_sort | efficacy of combination therapy involving excision followed by intralesional 5 fluorouracil and betamethasone and radiotherapy in the treatment of keloids a randomized controlled trial |
| topic | keloid excision 5-fluorouracil betamethasone radiotherapy |
| url | https://www.dovepress.com/the-efficacy-of-combination-therapy-involving-excision-followed-by-int-peer-reviewed-fulltext-article-CCID |
| work_keys_str_mv | AT liy theefficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT zhangd theefficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT hangb theefficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT wangh theefficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT liy efficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT zhangd efficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT hangb efficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial AT wangh efficacyofcombinationtherapyinvolvingexcisionfollowedbyintralesional5fluorouracilandbetamethasoneandradiotherapyinthetreatmentofkeloidsarandomizedcontrolledtrial |