Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions
Diffusion tensor imaging (DTI) studies have provided evidence of widespread white matter (WM) abnormalities in schizophrenia. Although these abnormalities appear clinically significant, the relationship to specific clinical symptoms is limited and heterogeneous. This study examined the association b...
| Հիմնական հեղինակներ: | , , , , , , , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
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Elsevier
2016-01-01
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| Շարք: | NeuroImage: Clinical |
| Խորագրեր: | |
| Առցանց հասանելիություն: | http://www.sciencedirect.com/science/article/pii/S2213158216301115 |
| _version_ | 1828863697806688256 |
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| author | Petra V. Viher Katharina Stegmayer Stéphanie Giezendanner Andrea Federspiel Stephan Bohlhalter Tim Vanbellingen Roland Wiest Werner Strik Sebastian Walther |
| author_facet | Petra V. Viher Katharina Stegmayer Stéphanie Giezendanner Andrea Federspiel Stephan Bohlhalter Tim Vanbellingen Roland Wiest Werner Strik Sebastian Walther |
| author_sort | Petra V. Viher |
| collection | DOAJ |
| description | Diffusion tensor imaging (DTI) studies have provided evidence of widespread white matter (WM) abnormalities in schizophrenia. Although these abnormalities appear clinically significant, the relationship to specific clinical symptoms is limited and heterogeneous. This study examined the association between WM microstructure and the severity of the five main DSM-5 schizophrenia symptom dimensions. DTI was measured in forty patients with schizophrenia spectrum disorders. Using Tract-Based Spatial Statistics controlling for age, gender and antipsychotic dosage, our analyses revealed significant negative relationships between WM microstructure and two DSM-5 symptom dimensions: Whereas abnormal psychomotor behavior was particularly related to WM of motor tracts, negative symptoms were associated with WM microstructure of the prefrontal and right temporal lobes. However, we found no associations between WM microstructure and delusions, hallucinations or disorganized speech. These data highlight the relevance of characteristic WM disconnectivity patterns as markers for negative symptoms and abnormal psychomotor behavior in schizophrenia and provide evidence for relevant associations between brain structure and aberrant behavior. |
| first_indexed | 2024-12-13T03:49:30Z |
| format | Article |
| id | doaj.art-535f3b64c10b4c4b8df0372ab901b02c |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-13T03:49:30Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-535f3b64c10b4c4b8df0372ab901b02c2022-12-22T00:00:44ZengElsevierNeuroImage: Clinical2213-15822016-01-0112C939910.1016/j.nicl.2016.06.013Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensionsPetra V. Viher0Katharina Stegmayer1Stéphanie Giezendanner2Andrea Federspiel3Stephan Bohlhalter4Tim Vanbellingen5Roland Wiest6Werner Strik7Sebastian Walther8Translational Research Center, University Hospital of Psychiatry, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry, Bern, SwitzerlandDepartment of Clinical Research, Inselspital, Bern, SwitzerlandDepartment of Clinical Research, Inselspital, Bern, SwitzerlandSupport Center of Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry, Bern, SwitzerlandDiffusion tensor imaging (DTI) studies have provided evidence of widespread white matter (WM) abnormalities in schizophrenia. Although these abnormalities appear clinically significant, the relationship to specific clinical symptoms is limited and heterogeneous. This study examined the association between WM microstructure and the severity of the five main DSM-5 schizophrenia symptom dimensions. DTI was measured in forty patients with schizophrenia spectrum disorders. Using Tract-Based Spatial Statistics controlling for age, gender and antipsychotic dosage, our analyses revealed significant negative relationships between WM microstructure and two DSM-5 symptom dimensions: Whereas abnormal psychomotor behavior was particularly related to WM of motor tracts, negative symptoms were associated with WM microstructure of the prefrontal and right temporal lobes. However, we found no associations between WM microstructure and delusions, hallucinations or disorganized speech. These data highlight the relevance of characteristic WM disconnectivity patterns as markers for negative symptoms and abnormal psychomotor behavior in schizophrenia and provide evidence for relevant associations between brain structure and aberrant behavior.http://www.sciencedirect.com/science/article/pii/S2213158216301115Diffusion tensor imagingTract-Based Spatial StatisticsNeurobiological correlatesNegative syndromeMotor abnormalities |
| spellingShingle | Petra V. Viher Katharina Stegmayer Stéphanie Giezendanner Andrea Federspiel Stephan Bohlhalter Tim Vanbellingen Roland Wiest Werner Strik Sebastian Walther Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions NeuroImage: Clinical Diffusion tensor imaging Tract-Based Spatial Statistics Neurobiological correlates Negative syndrome Motor abnormalities |
| title | Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions |
| title_full | Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions |
| title_fullStr | Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions |
| title_full_unstemmed | Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions |
| title_short | Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions |
| title_sort | cerebral white matter structure is associated with dsm 5 schizophrenia symptom dimensions |
| topic | Diffusion tensor imaging Tract-Based Spatial Statistics Neurobiological correlates Negative syndrome Motor abnormalities |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216301115 |
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