ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY
The retrospective study was designed to identify association of premature rupture of the fetal membranes (PROM) with carrying polymorphisms in genes encoding folate metabolism and hemostasis in 717 women. More than one hundred potential predictors were analyzed including carriage of thrombogenic gen...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2013-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/299 |
| _version_ | 1827991649320435712 |
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| author | M. G. Nikolayeva G. V. Serdyuk Ye. Ye. Grigoriyeva |
| author_facet | M. G. Nikolayeva G. V. Serdyuk Ye. Ye. Grigoriyeva |
| author_sort | M. G. Nikolayeva |
| collection | DOAJ |
| description | The retrospective study was designed to identify association of premature rupture of the fetal membranes (PROM) with carrying polymorphisms in genes encoding folate metabolism and hemostasis in 717 women. More than one hundred potential predictors were analyzed including carriage of thrombogenic genes polymorphisms and genes encoding folate metabolism: FV[Arg506Gln], F II [20210 G/A], MTHFR [Ala222Val], (PAI-I)[-675 5G/4G]. Study revealed that plasminogen activator ingibitor-1 gene polymorphism increases significantly the risk of premature rupture of the fetal membranes in term pregnancy (PROM): heterozygous plasminogen activator ingibitor-1 gene polymorphism is associated with 3.6-fold (95% CI 2.4–5.4; p < 0.001), homozygous plasminogen activator ingibitor-1 gene polymorphism – with 1.7-fold (95% CI 1.1–2.6; p = 0.01) risk rise of PROM. |
| first_indexed | 2024-04-10T01:08:35Z |
| format | Article |
| id | doaj.art-5360d602a1c5411798d27a70e87eecf3 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:08:35Z |
| publishDate | 2013-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-5360d602a1c5411798d27a70e87eecf32023-03-13T09:58:19ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-12-01126434710.20538/1682-0363-2013-6-43-47296ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCYM. G. Nikolayeva0G. V. Serdyuk1Ye. Ye. Grigoriyeva2Алтайский государственный медицинский университет, БарнаулАлтайский филиал Гематологическго научнго центра Министерства здравоохранения и социального развития РФ, БарнаулГлавное управление Алтайского края по здравоохранению и фармакологической деятельности, БарнаулThe retrospective study was designed to identify association of premature rupture of the fetal membranes (PROM) with carrying polymorphisms in genes encoding folate metabolism and hemostasis in 717 women. More than one hundred potential predictors were analyzed including carriage of thrombogenic genes polymorphisms and genes encoding folate metabolism: FV[Arg506Gln], F II [20210 G/A], MTHFR [Ala222Val], (PAI-I)[-675 5G/4G]. Study revealed that plasminogen activator ingibitor-1 gene polymorphism increases significantly the risk of premature rupture of the fetal membranes in term pregnancy (PROM): heterozygous plasminogen activator ingibitor-1 gene polymorphism is associated with 3.6-fold (95% CI 2.4–5.4; p < 0.001), homozygous plasminogen activator ingibitor-1 gene polymorphism – with 1.7-fold (95% CI 1.1–2.6; p = 0.01) risk rise of PROM.https://bulletin.ssmu.ru/jour/article/view/299преждевременный разрыв плодных оболочек, полиморфизм генов гемостаза, факторы риска |
| spellingShingle | M. G. Nikolayeva G. V. Serdyuk Ye. Ye. Grigoriyeva ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY Бюллетень сибирской медицины преждевременный разрыв плодных оболочек, полиморфизм генов гемостаза, факторы риска |
| title | ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY |
| title_full | ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY |
| title_fullStr | ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY |
| title_full_unstemmed | ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY |
| title_short | ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY |
| title_sort | role of gene polymorfism of plasminogen activator ingibitor type i as a risk factor for premature rupture of membrane at term pregnancy |
| topic | преждевременный разрыв плодных оболочек, полиморфизм генов гемостаза, факторы риска |
| url | https://bulletin.ssmu.ru/jour/article/view/299 |
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