Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study
ObjectiveTo assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patien...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1133705/full |
| _version_ | 1811155424140853248 |
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| author | Xiaoxia Zhou Yaqin Xiang Tingwei Song Yuwen Zhao Hongxu Pan Qian Xu Yase Chen Qiying Sun Qiying Sun Xinyin Wu Xinxiang Yan Xinxiang Yan Jifeng Guo Jifeng Guo Jifeng Guo Beisha Tang Beisha Tang Beisha Tang Lifang Lei Zhenhua Liu Zhenhua Liu Zhenhua Liu for Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC) |
| author_facet | Xiaoxia Zhou Yaqin Xiang Tingwei Song Yuwen Zhao Hongxu Pan Qian Xu Yase Chen Qiying Sun Qiying Sun Xinyin Wu Xinxiang Yan Xinxiang Yan Jifeng Guo Jifeng Guo Jifeng Guo Beisha Tang Beisha Tang Beisha Tang Lifang Lei Zhenhua Liu Zhenhua Liu Zhenhua Liu for Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC) |
| author_sort | Xiaoxia Zhou |
| collection | DOAJ |
| description | ObjectiveTo assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patients with Parkinson’s disease (PD).Materials and methodsA total of 2,100 PD patients were enrolled from the Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), and their motor and non-motor symptoms were assessed biennially using comprehensive scales, including the 16-item Parkinson Fatigue Scale (PFS-16). Each PD patient was categorized as PD with or without fatigue on the basis of a cut-off mean PFS-16 score of 3.3.ResultsThe prevalence of fatigue in our cohort was 36.8%. Compared to PD patients without fatigue, PD patients with fatigue were more likely to be older, have a longer disease duration, and higher baseline levodopa equivalent daily dose (all p < 0.05). Moreover, PD patients with fatigue showed more severe motor and non-motor phenotypes than those without fatigue. Overall, high total Unified Parkinson’s Disease Rating Scale (UPDRS) score (odds ratio [OR] = 1.016, 95% confidence interval [CI]: 1.009–1.024), Non-Motor Symptoms Scale score (OR = 1.022, 95% CI: 1.015–1.029), postural instability and gait difficulty (PIGD) subtype (OR = 1.586, 95% CI: 1.211–2.079), presence of excessive daytime sleepiness (EDS; OR = 1.343, 95% CI: 1.083–1.666), and wearing-off (OR = 1.282, 95% CI: 1.023–1.607) were significantly associated with fatigue in PD patients (all p < 0.05). High total UPDRS score at baseline (OR = 1.014, 95% CI: 1.002–1.027, p = 0.028) increased the risk of developing fatigue during follow-up. Although significant, the odds ratios were low and confidence intervals were narrow. Analysis of disease progression showed significant group differences in motor and non-motor symptoms. In comparison with the never-fatigue group, the persistent-fatigue group showed significantly greater progression in motor, autonomic dysfunction, sleep, depression and cognitive symptoms (all p < 0.05).ConclusionIncreased disease severity, presence of the PIGD subtype, EDS, and wearing-off were associated with fatigue in PD patients. Significant subgroup-level differences were observed in the progression of motor and non-motor symptoms across different fatigue subgroups of PD patients. |
| first_indexed | 2024-04-10T04:33:47Z |
| format | Article |
| id | doaj.art-536156752cc34852aa50a493b5719daa |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-10T04:33:47Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-536156752cc34852aa50a493b5719daa2023-03-10T04:56:59ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-03-011510.3389/fnagi.2023.11337051133705Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort studyXiaoxia Zhou0Yaqin Xiang1Tingwei Song2Yuwen Zhao3Hongxu Pan4Qian Xu5Yase Chen6Qiying Sun7Qiying Sun8Xinyin Wu9Xinxiang Yan10Xinxiang Yan11Jifeng Guo12Jifeng Guo13Jifeng Guo14Beisha Tang15Beisha Tang16Beisha Tang17Lifang Lei18Zhenhua Liu19Zhenhua Liu20Zhenhua Liu21for Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC)Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaObjectiveTo assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patients with Parkinson’s disease (PD).Materials and methodsA total of 2,100 PD patients were enrolled from the Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), and their motor and non-motor symptoms were assessed biennially using comprehensive scales, including the 16-item Parkinson Fatigue Scale (PFS-16). Each PD patient was categorized as PD with or without fatigue on the basis of a cut-off mean PFS-16 score of 3.3.ResultsThe prevalence of fatigue in our cohort was 36.8%. Compared to PD patients without fatigue, PD patients with fatigue were more likely to be older, have a longer disease duration, and higher baseline levodopa equivalent daily dose (all p < 0.05). Moreover, PD patients with fatigue showed more severe motor and non-motor phenotypes than those without fatigue. Overall, high total Unified Parkinson’s Disease Rating Scale (UPDRS) score (odds ratio [OR] = 1.016, 95% confidence interval [CI]: 1.009–1.024), Non-Motor Symptoms Scale score (OR = 1.022, 95% CI: 1.015–1.029), postural instability and gait difficulty (PIGD) subtype (OR = 1.586, 95% CI: 1.211–2.079), presence of excessive daytime sleepiness (EDS; OR = 1.343, 95% CI: 1.083–1.666), and wearing-off (OR = 1.282, 95% CI: 1.023–1.607) were significantly associated with fatigue in PD patients (all p < 0.05). High total UPDRS score at baseline (OR = 1.014, 95% CI: 1.002–1.027, p = 0.028) increased the risk of developing fatigue during follow-up. Although significant, the odds ratios were low and confidence intervals were narrow. Analysis of disease progression showed significant group differences in motor and non-motor symptoms. In comparison with the never-fatigue group, the persistent-fatigue group showed significantly greater progression in motor, autonomic dysfunction, sleep, depression and cognitive symptoms (all p < 0.05).ConclusionIncreased disease severity, presence of the PIGD subtype, EDS, and wearing-off were associated with fatigue in PD patients. Significant subgroup-level differences were observed in the progression of motor and non-motor symptoms across different fatigue subgroups of PD patients.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1133705/fullParkinson’s diseasefatiguelongitudinalPD-MDCNCprogression |
| spellingShingle | Xiaoxia Zhou Yaqin Xiang Tingwei Song Yuwen Zhao Hongxu Pan Qian Xu Yase Chen Qiying Sun Qiying Sun Xinyin Wu Xinxiang Yan Xinxiang Yan Jifeng Guo Jifeng Guo Jifeng Guo Beisha Tang Beisha Tang Beisha Tang Lifang Lei Zhenhua Liu Zhenhua Liu Zhenhua Liu for Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC) Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study Frontiers in Aging Neuroscience Parkinson’s disease fatigue longitudinal PD-MDCNC progression |
| title | Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study |
| title_full | Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study |
| title_fullStr | Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study |
| title_full_unstemmed | Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study |
| title_short | Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study |
| title_sort | characteristics of fatigue in parkinson s disease a longitudinal cohort study |
| topic | Parkinson’s disease fatigue longitudinal PD-MDCNC progression |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1133705/full |
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