Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/6/1504 |
| _version_ | 1797540782239907840 |
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| author | Hyunsik Choi Mina Kwon Hye Eun Choi Sei Kwang Hahn Ki Su Kim |
| author_facet | Hyunsik Choi Mina Kwon Hye Eun Choi Sei Kwang Hahn Ki Su Kim |
| author_sort | Hyunsik Choi |
| collection | DOAJ |
| description | Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via “click” chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs. |
| first_indexed | 2024-03-10T13:06:42Z |
| format | Article |
| id | doaj.art-536550c066d64129b50277c39542e944 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T13:06:42Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-536550c066d64129b50277c39542e9442023-11-21T11:05:59ZengMDPI AGMaterials1996-19442021-03-01146150410.3390/ma14061504Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click ChemistryHyunsik Choi0Mina Kwon1Hye Eun Choi2Sei Kwang Hahn3Ki Su Kim4Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77-Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 790-784, KoreaSchool of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, KoreaSchool of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, KoreaDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77-Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 790-784, KoreaSchool of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, KoreaHyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via “click” chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs.https://www.mdpi.com/1996-1944/14/6/1504hyaluronateclick chemistrynanogelnoninvasivedrug delivery |
| spellingShingle | Hyunsik Choi Mina Kwon Hye Eun Choi Sei Kwang Hahn Ki Su Kim Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry Materials hyaluronate click chemistry nanogel noninvasive drug delivery |
| title | Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry |
| title_full | Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry |
| title_fullStr | Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry |
| title_full_unstemmed | Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry |
| title_short | Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry |
| title_sort | non invasive topical drug delivery system using hyaluronate nanogels crosslinked via click chemistry |
| topic | hyaluronate click chemistry nanogel noninvasive drug delivery |
| url | https://www.mdpi.com/1996-1944/14/6/1504 |
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