Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study
Band keratopathy (BK) is a common complication in aphakic eyes with silicone oil tamponade for open-globe injury (OGI), characterized by the grayish-white opacities in the cornea, resulting in a significantly decreased vision when extending to the visual axis. To identify the risk factors for BK in...
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| Format: | Article |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.713599/full |
| _version_ | 1818671473442684928 |
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| author | Kai He Mengyu Liao Yun Zhu Bohao Cui Haoyu Chen Ting Wang Nan Wu Zhenggao Xie Jing Luo Yong Wei Zhiliang Wang Heding Zhou Zhansheng Shen Hua Yan |
| author_facet | Kai He Mengyu Liao Yun Zhu Bohao Cui Haoyu Chen Ting Wang Nan Wu Zhenggao Xie Jing Luo Yong Wei Zhiliang Wang Heding Zhou Zhansheng Shen Hua Yan |
| author_sort | Kai He |
| collection | DOAJ |
| description | Band keratopathy (BK) is a common complication in aphakic eyes with silicone oil tamponade for open-globe injury (OGI), characterized by the grayish-white opacities in the cornea, resulting in a significantly decreased vision when extending to the visual axis. To identify the risk factors for BK in aphakic eyes following vitreoretinal surgical treatment with silicone oil tamponade for OGIs, we performed a multicenter case-control study. The incidence of BK was 28% (28/100 eyes). The multivariate binary logistic regression revealed the silicone oil retention time (SORT) ≥6 months and zone III injury were significant risk factors for BK. From the hierarchical interaction, SORT ≥6 months had a significant risk for BK in eyes with rupture, aniridia, and zone III injury, while zone III injury had a significant risk for BK in eyes with rupture, incomplete/complete iris, and SORT ≥6 months. By using restricted cubic splines with three knots at the 25th, 50th, and 75th centiles to model the association of SORT with BK, we also found a marked increase in the risk for BK at ≥10 months and a slow increase after 6 months, but almost stable within 4–6 months. |
| first_indexed | 2024-12-17T07:24:34Z |
| format | Article |
| id | doaj.art-5365e55ad85d447b8a0ef4d596e5dc2f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-17T07:24:34Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5365e55ad85d447b8a0ef4d596e5dc2f2022-12-21T21:58:40ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.713599713599Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control StudyKai He0Mengyu Liao1Yun Zhu2Bohao Cui3Haoyu Chen4Ting Wang5Nan Wu6Zhenggao Xie7Jing Luo8Yong Wei9Zhiliang Wang10Heding Zhou11Zhansheng Shen12Hua Yan13Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, ChinaState Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Department of Ophthalmology, Shandong Eye Institute, Eye Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Ophthalmology, Southwest Hospital, Southwest Eye Hospital, Army Medical University, Chongqing, ChinaDepartment of Ophthalmology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, ChinaThe Eye Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China0Department of Ophthalmology, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China1Department of Ophthalmology, Zhengzhou Second Hospital, Zhengzhou, ChinaDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, ChinaBand keratopathy (BK) is a common complication in aphakic eyes with silicone oil tamponade for open-globe injury (OGI), characterized by the grayish-white opacities in the cornea, resulting in a significantly decreased vision when extending to the visual axis. To identify the risk factors for BK in aphakic eyes following vitreoretinal surgical treatment with silicone oil tamponade for OGIs, we performed a multicenter case-control study. The incidence of BK was 28% (28/100 eyes). The multivariate binary logistic regression revealed the silicone oil retention time (SORT) ≥6 months and zone III injury were significant risk factors for BK. From the hierarchical interaction, SORT ≥6 months had a significant risk for BK in eyes with rupture, aniridia, and zone III injury, while zone III injury had a significant risk for BK in eyes with rupture, incomplete/complete iris, and SORT ≥6 months. By using restricted cubic splines with three knots at the 25th, 50th, and 75th centiles to model the association of SORT with BK, we also found a marked increase in the risk for BK at ≥10 months and a slow increase after 6 months, but almost stable within 4–6 months.https://www.frontiersin.org/articles/10.3389/fmed.2021.713599/fullband keratopathyopen-globe injuriessilicone oil tamponadeaphakic eyezone of injurysilicone oil retention time |
| spellingShingle | Kai He Mengyu Liao Yun Zhu Bohao Cui Haoyu Chen Ting Wang Nan Wu Zhenggao Xie Jing Luo Yong Wei Zhiliang Wang Heding Zhou Zhansheng Shen Hua Yan Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study Frontiers in Medicine band keratopathy open-globe injuries silicone oil tamponade aphakic eye zone of injury silicone oil retention time |
| title | Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study |
| title_full | Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study |
| title_fullStr | Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study |
| title_full_unstemmed | Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study |
| title_short | Risk Factors for Band Keratopathy in Aphakic Eyes With Silicone Oil Tamponade for Open-Globe Injuries: A Multicenter Case-Control Study |
| title_sort | risk factors for band keratopathy in aphakic eyes with silicone oil tamponade for open globe injuries a multicenter case control study |
| topic | band keratopathy open-globe injuries silicone oil tamponade aphakic eye zone of injury silicone oil retention time |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.713599/full |
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