PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study
Abstract Background Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individual...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-022-02958-x |
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| author | L. Willacker T. M. Raiser M. Bassi A. Bender A. Comanducci M. Rosanova N. Sobel A. Arzi L. Belloli S. Casarotto M. Colombo C. C. Derchi E. Fló Rama E. Grill M. Hohl K. Kuehlmeyer D. Manasova M. J. Rosenfelder C. Valota J. D. Sitt |
| author_facet | L. Willacker T. M. Raiser M. Bassi A. Bender A. Comanducci M. Rosanova N. Sobel A. Arzi L. Belloli S. Casarotto M. Colombo C. C. Derchi E. Fló Rama E. Grill M. Hohl K. Kuehlmeyer D. Manasova M. J. Rosenfelder C. Valota J. D. Sitt |
| author_sort | L. Willacker |
| collection | DOAJ |
| description | Abstract Background Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individualizing diagnostic and prognostic accuracy for patients affected by DoC have been made, mainly focusing on introducing multimodal assessments to complement behavioral examination. The present EU-funded multicentric research project “PerBrain” is aimed at developing an individualized diagnostic hierarchical pathway guided by both behavior and multimodal neurodiagnostics for DoC patients. Methods In this project, each enrolled patient undergoes repetitive behavioral, clinical, and neurodiagnostic assessments according to a patient-tailored multi-layer workflow. Multimodal diagnostic acquisitions using state-of-the-art techniques at different stages of the patients’ clinical evolution are performed. The techniques applied comprise well-established behavioral scales, innovative neurophysiological techniques (such as quantitative electroencephalography and transcranial magnetic stimulation combined with electroencephalography), structural and resting-state functional magnetic resonance imaging, and measurements of physiological activity (i.e. nasal airflow respiration). In addition, the well-being and treatment decision attitudes of patients’ informal caregivers (primarily family members) are investigated. Patient and caregiver assessments are performed at multiple time points within one year after acquired brain injury, starting at the acute disease phase. Discussion Accurate classification and outcome prediction of DoC are of crucial importance for affected patients as well as their caregivers, as individual rehabilitation strategies and treatment decisions are critically dependent on the latter. The PerBrain project aims at optimizing individual DoC diagnosis and accuracy of outcome prediction by integrating data from the suggested multimodal examination methods into a personalized hierarchical diagnosis and prognosis procedure. Using the parallel tracking of both patients’ neurological status and their caregivers’ mental situation, well-being, and treatment decision attitudes from the acute to the chronic phase of the disease and across different countries, this project aims at significantly contributing to the current clinical routine of DoC patients and their family members. Trial registration ClinicalTrials.gov, NCT04798456 . Registered 15 March 2021 – Retrospectively registered. |
| first_indexed | 2024-04-11T14:27:45Z |
| format | Article |
| id | doaj.art-536638c61af0480ca78a1eb4a80782b8 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-11T14:27:45Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-536638c61af0480ca78a1eb4a80782b82022-12-22T04:18:48ZengBMCBMC Neurology1471-23772022-12-0122111110.1186/s12883-022-02958-xPerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational studyL. Willacker0T. M. Raiser1M. Bassi2A. Bender3A. Comanducci4M. Rosanova5N. Sobel6A. Arzi7L. Belloli8S. Casarotto9M. Colombo10C. C. Derchi11E. Fló Rama12E. Grill13M. Hohl14K. Kuehlmeyer15D. Manasova16M. J. Rosenfelder17C. Valota18J. D. Sitt19Department of Neurology, University Hospital of the Ludwig-Maximilians-Universität MünchenDepartment of Neurology, University Hospital of the Ludwig-Maximilians-Universität MünchenDepartment of Biomedical and Clinical Sciences, University of MilanoDepartment of Neurology, University Hospital of the Ludwig-Maximilians-Universität MünchenIRCCS Fondazione Don Carlo Gnocchi ONLUSDepartment of Biomedical and Clinical Sciences, University of MilanoDepartment of Brain Sciences, Weizmann Institute of ScienceSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRSSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRSDepartment of Biomedical and Clinical Sciences, University of MilanoDepartment of Biomedical and Clinical Sciences, University of MilanoIRCCS Fondazione Don Carlo Gnocchi ONLUSSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRSInstitute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität MünchenDepartment of Neurology, University Hospital of the Ludwig-Maximilians-Universität MünchenInstitute of Ethics, History and Theory of Medicine, Ludwig-Maximilians-Universität MünchenSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRSTherapiezentrum Burgau, Hospital for Neurological RehabilitationDepartment of Biomedical and Clinical Sciences, University of MilanoSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRSAbstract Background Disorders of consciousness (DoC) are severe neurological conditions in which consciousness is impaired to various degrees. They are caused by injury or malfunction of neural systems regulating arousal and awareness. Over the last decades, major efforts in improving and individualizing diagnostic and prognostic accuracy for patients affected by DoC have been made, mainly focusing on introducing multimodal assessments to complement behavioral examination. The present EU-funded multicentric research project “PerBrain” is aimed at developing an individualized diagnostic hierarchical pathway guided by both behavior and multimodal neurodiagnostics for DoC patients. Methods In this project, each enrolled patient undergoes repetitive behavioral, clinical, and neurodiagnostic assessments according to a patient-tailored multi-layer workflow. Multimodal diagnostic acquisitions using state-of-the-art techniques at different stages of the patients’ clinical evolution are performed. The techniques applied comprise well-established behavioral scales, innovative neurophysiological techniques (such as quantitative electroencephalography and transcranial magnetic stimulation combined with electroencephalography), structural and resting-state functional magnetic resonance imaging, and measurements of physiological activity (i.e. nasal airflow respiration). In addition, the well-being and treatment decision attitudes of patients’ informal caregivers (primarily family members) are investigated. Patient and caregiver assessments are performed at multiple time points within one year after acquired brain injury, starting at the acute disease phase. Discussion Accurate classification and outcome prediction of DoC are of crucial importance for affected patients as well as their caregivers, as individual rehabilitation strategies and treatment decisions are critically dependent on the latter. The PerBrain project aims at optimizing individual DoC diagnosis and accuracy of outcome prediction by integrating data from the suggested multimodal examination methods into a personalized hierarchical diagnosis and prognosis procedure. Using the parallel tracking of both patients’ neurological status and their caregivers’ mental situation, well-being, and treatment decision attitudes from the acute to the chronic phase of the disease and across different countries, this project aims at significantly contributing to the current clinical routine of DoC patients and their family members. Trial registration ClinicalTrials.gov, NCT04798456 . Registered 15 March 2021 – Retrospectively registered.https://doi.org/10.1186/s12883-022-02958-xDisorders of consciousnessMultimodal neurodiagnosticOutcome predictionCaregiver well-beingMachine learningMulticentric evaluation |
| spellingShingle | L. Willacker T. M. Raiser M. Bassi A. Bender A. Comanducci M. Rosanova N. Sobel A. Arzi L. Belloli S. Casarotto M. Colombo C. C. Derchi E. Fló Rama E. Grill M. Hohl K. Kuehlmeyer D. Manasova M. J. Rosenfelder C. Valota J. D. Sitt PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study BMC Neurology Disorders of consciousness Multimodal neurodiagnostic Outcome prediction Caregiver well-being Machine learning Multicentric evaluation |
| title | PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study |
| title_full | PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study |
| title_fullStr | PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study |
| title_full_unstemmed | PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study |
| title_short | PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study |
| title_sort | perbrain a multimodal approach to personalized tracking of evolving state of consciousness in brain injured patients protocol of an international multicentric observational study |
| topic | Disorders of consciousness Multimodal neurodiagnostic Outcome prediction Caregiver well-being Machine learning Multicentric evaluation |
| url | https://doi.org/10.1186/s12883-022-02958-x |
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