Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis
Alopecia areata is an autoimmune disorder characterized by hair loss, for which there are few treatment options. This claims-based study characterized recent real-world treatment patterns among patients in the USA with alopecia areata, including the subtypes alopecia totalis and alopecia universalis...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2023-08-01
|
| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/12445 |
| _version_ | 1797737214070751232 |
|---|---|
| author | Nicolae Done Lauren Bartolome Elyse Swallow Wei Gao Christopher Carley Travis Wang Arash Mostaghimi |
| author_facet | Nicolae Done Lauren Bartolome Elyse Swallow Wei Gao Christopher Carley Travis Wang Arash Mostaghimi |
| author_sort | Nicolae Done |
| collection | DOAJ |
| description | Alopecia areata is an autoimmune disorder characterized by hair loss, for which there are few treatment options. This claims-based study characterized recent real-world treatment patterns among patients in the USA with alopecia areata, including the subtypes alopecia totalis and alopecia universalis, in the first year after diagnosis of an episode of alopecia areata. Approximately 5% of all patients (adults (age ≥ 18 years), n = 7,703; adolescents (age 12–17 years), n = 595) had alopecia totalis or alopecia universalis. Corticosteroids were the most common first-line (1L) and second-line (2L) treatments. The mean time from diagnosis of alopecia areata to initiation of 1L treatment was 2.2 days for adults and 2.6 days for adolescents; mean 1L duration was 76.9 and 64.3 days, respectively. For adults (57.5%) and adolescents (59.7%) with 2L therapy, the mean time from 1L discontinuation to 2L initiation was 57.2 and 53.6 days, respectively; the mean duration of 2L treatment was 55.5 and 50.1 days, respectively. More patients with vs without alopecia totalis or alopecia universalis initiated 2L therapy (adults: 71.9% vs 56.8%; adolescents: 71.4% vs 58.9%). The proportion of days covered during the first year post-diagnosis was 36.7% (adults) and 34.1% (adolescents). These results highlight the substantial disease burden of alopecia areata and a need for more effective treatments.
|
| first_indexed | 2024-03-12T13:25:14Z |
| format | Article |
| id | doaj.art-5366461a22b8455b864b6c81d608c406 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-03-12T13:25:14Z |
| publishDate | 2023-08-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-5366461a22b8455b864b6c81d608c4062023-08-25T08:03:12ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-08-0110310.2340/actadv.v103.12445Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims AnalysisNicolae Done0Lauren Bartolome1Elyse Swallow2Wei Gao3Christopher Carley4Travis Wang5Arash Mostaghimi6Analysis Group, Boston, MA, USPfizer, Collegeville, PA, USAAnalysis Group, Boston, MA, USAnalysis Group, Boston, MA, USAnalysis Group, Boston, MA, USAnalysis Group, Boston, MA, USBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAAlopecia areata is an autoimmune disorder characterized by hair loss, for which there are few treatment options. This claims-based study characterized recent real-world treatment patterns among patients in the USA with alopecia areata, including the subtypes alopecia totalis and alopecia universalis, in the first year after diagnosis of an episode of alopecia areata. Approximately 5% of all patients (adults (age ≥ 18 years), n = 7,703; adolescents (age 12–17 years), n = 595) had alopecia totalis or alopecia universalis. Corticosteroids were the most common first-line (1L) and second-line (2L) treatments. The mean time from diagnosis of alopecia areata to initiation of 1L treatment was 2.2 days for adults and 2.6 days for adolescents; mean 1L duration was 76.9 and 64.3 days, respectively. For adults (57.5%) and adolescents (59.7%) with 2L therapy, the mean time from 1L discontinuation to 2L initiation was 57.2 and 53.6 days, respectively; the mean duration of 2L treatment was 55.5 and 50.1 days, respectively. More patients with vs without alopecia totalis or alopecia universalis initiated 2L therapy (adults: 71.9% vs 56.8%; adolescents: 71.4% vs 58.9%). The proportion of days covered during the first year post-diagnosis was 36.7% (adults) and 34.1% (adolescents). These results highlight the substantial disease burden of alopecia areata and a need for more effective treatments. https://medicaljournalssweden.se/actadv/article/view/12445alopecia areataalopecia totalisalopecia universalistreatmentadultadolescent |
| spellingShingle | Nicolae Done Lauren Bartolome Elyse Swallow Wei Gao Christopher Carley Travis Wang Arash Mostaghimi Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis Acta Dermato-Venereologica alopecia areata alopecia totalis alopecia universalis treatment adult adolescent |
| title | Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis |
| title_full | Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis |
| title_fullStr | Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis |
| title_full_unstemmed | Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis |
| title_short | Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis |
| title_sort | real world treatment patterns among patients with alopecia areata in the usa a retrospective claims analysis |
| topic | alopecia areata alopecia totalis alopecia universalis treatment adult adolescent |
| url | https://medicaljournalssweden.se/actadv/article/view/12445 |
| work_keys_str_mv | AT nicolaedone realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis AT laurenbartolome realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis AT elyseswallow realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis AT weigao realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis AT christophercarley realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis AT traviswang realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis AT arashmostaghimi realworldtreatmentpatternsamongpatientswithalopeciaareataintheusaaretrospectiveclaimsanalysis |