Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion
Ureaplasma urealyticum can colonize women genital tract and be isolated from the amniotic fluid of women with adverse pregnancy outcomes. The association of U. urealyticum with spontaneous abortion remains controversial. The aim of this study was to evaluate the frequency of U. urealyticum infection...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2014-12-01
|
| Series: | Iranian Journal of Microbiology |
| Subjects: | |
| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/366 |
| _version_ | 1818872014001143808 |
|---|---|
| author | Amjad Ahmadi Mazaher Khodabandehloo Rashid Ramazanzadeh Fariba Farhadifar Bahram Nikkhoo Nasrin Soofizade Masoome Rezaii |
| author_facet | Amjad Ahmadi Mazaher Khodabandehloo Rashid Ramazanzadeh Fariba Farhadifar Bahram Nikkhoo Nasrin Soofizade Masoome Rezaii |
| author_sort | Amjad Ahmadi |
| collection | DOAJ |
| description | Ureaplasma urealyticum can colonize women genital tract and be isolated from the amniotic fluid of women with adverse pregnancy outcomes. The association of U. urealyticum with spontaneous abortion remains controversial. The aim of this study was to evaluate the frequency of U. urealyticum infection among pregnant women and its association with spontaneous abortion.In this case-control study we included 109 women with spontaneous abortion with gestation age between 10-20 weeks (Cases), and 109 women with normal pregnancy with gestation age between 20-30 weeks (Controls) in Sanandaj, Iran. Using specific primers and extracted DNA from endocervical swabs, a PCR test was conducted for detection of U. urealyticum in both women groups.Total prevalence of U. urealyticum infection in women was 26 out of 218 cases (11.92%). The prevalence of U. urealyticum infection was 18 out of 109 (16.5%) and 8 out of 109 (7.3%) in case (spontaneous abortion) and control groups, respectively. Using chi-square test, association between U. urealyticum infection and spontaneous abortion was statistically significant (P<0.05).Colonization of U. urealyticum in genital tract of women, and its asymptomatic feature in combination with other factors such as other microorganisms or cervical incompetence may induce spontaneous abortion. Further studies are needed to confirm this possibility. |
| first_indexed | 2024-12-19T12:32:04Z |
| format | Article |
| id | doaj.art-5367014592f9450e8a4355dd5e60f453 |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-19T12:32:04Z |
| publishDate | 2014-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-5367014592f9450e8a4355dd5e60f4532022-12-21T20:21:18ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472014-12-0166Association between Ureaplasma urealyticum endocervical infection and spontaneous abortionAmjad Ahmadi0Mazaher Khodabandehloo1Rashid Ramazanzadeh2Fariba Farhadifar3Bahram Nikkhoo4Nasrin Soofizade5Masoome Rezaii6Student of Research Committee, Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Microbiology, Faculty of Medicine &Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Microbiology, Faculty of Medicine &Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Genecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Pathology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Genecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Genecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Ureaplasma urealyticum can colonize women genital tract and be isolated from the amniotic fluid of women with adverse pregnancy outcomes. The association of U. urealyticum with spontaneous abortion remains controversial. The aim of this study was to evaluate the frequency of U. urealyticum infection among pregnant women and its association with spontaneous abortion.In this case-control study we included 109 women with spontaneous abortion with gestation age between 10-20 weeks (Cases), and 109 women with normal pregnancy with gestation age between 20-30 weeks (Controls) in Sanandaj, Iran. Using specific primers and extracted DNA from endocervical swabs, a PCR test was conducted for detection of U. urealyticum in both women groups.Total prevalence of U. urealyticum infection in women was 26 out of 218 cases (11.92%). The prevalence of U. urealyticum infection was 18 out of 109 (16.5%) and 8 out of 109 (7.3%) in case (spontaneous abortion) and control groups, respectively. Using chi-square test, association between U. urealyticum infection and spontaneous abortion was statistically significant (P<0.05).Colonization of U. urealyticum in genital tract of women, and its asymptomatic feature in combination with other factors such as other microorganisms or cervical incompetence may induce spontaneous abortion. Further studies are needed to confirm this possibility.https://ijm.tums.ac.ir/index.php/ijm/article/view/366Ureaplasma urealyticumendocervical infectionpregnancy outcomesspontaneous abortion |
| spellingShingle | Amjad Ahmadi Mazaher Khodabandehloo Rashid Ramazanzadeh Fariba Farhadifar Bahram Nikkhoo Nasrin Soofizade Masoome Rezaii Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion Iranian Journal of Microbiology Ureaplasma urealyticum endocervical infection pregnancy outcomes spontaneous abortion |
| title | Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion |
| title_full | Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion |
| title_fullStr | Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion |
| title_full_unstemmed | Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion |
| title_short | Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion |
| title_sort | association between ureaplasma urealyticum endocervical infection and spontaneous abortion |
| topic | Ureaplasma urealyticum endocervical infection pregnancy outcomes spontaneous abortion |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/366 |
| work_keys_str_mv | AT amjadahmadi associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion AT mazaherkhodabandehloo associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion AT rashidramazanzadeh associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion AT faribafarhadifar associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion AT bahramnikkhoo associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion AT nasrinsoofizade associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion AT masoomerezaii associationbetweenureaplasmaurealyticumendocervicalinfectionandspontaneousabortion |