Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study
Abstract Objective To evaluate the prognostic significance of microscopic bile duct invasion (MiBDI) in hepatocellular carcinoma (HCC) following R0 resection. Patients and Methods Patients who underwent R0 resection for HCC at nine medical centers were stratified into five groups: neither bile duct...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6650 |
| _version_ | 1827216930854928384 |
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| author | Qizhen Huang Kongying Lin Zhipeng Lin Hongbin Ji Xiaoyu Zhou Bin Wang Yufeng Chen Chuandong Sun Shuguo Zheng Jinhong Chen Yifan Wang Yanming Zhou Weiping Zhou Yongyi Zeng |
| author_facet | Qizhen Huang Kongying Lin Zhipeng Lin Hongbin Ji Xiaoyu Zhou Bin Wang Yufeng Chen Chuandong Sun Shuguo Zheng Jinhong Chen Yifan Wang Yanming Zhou Weiping Zhou Yongyi Zeng |
| author_sort | Qizhen Huang |
| collection | DOAJ |
| description | Abstract Objective To evaluate the prognostic significance of microscopic bile duct invasion (MiBDI) in hepatocellular carcinoma (HCC) following R0 resection. Patients and Methods Patients who underwent R0 resection for HCC at nine medical centers were stratified into five groups: neither bile duct nor vascular invasion (MiBDI−MVI−), microscopic bile duct invasion alone (MiBDI+MVI−), both microscopic bile duct and vascular invasion (MiBDI+MVI+), microscopic vascular invasion alone (MiBDI−MVI+), and macroscopic bile duct invasion (MaBDI). Overall survival (OS) was assessed using Kaplan–Meier analysis, and independent risk factors of OS were determined using Cox proportional hazards models. Results A total of 377 HCC cases were analyzed. The OS for MiBDI+MVI‐ was similar to that of MiBDI−MVI− (p > 0.05) but better than MiBDI+MVI+, MiBDI−MVI+, and MaBDI (all p < 0.05). Multivariate analysis indicated that MiBDI was not an independent risk factor for OS, while MVI and MaBDI were. Conclusions Overall survival (OS) in patients with MiBDI was superior to those with MVI and MaBDI. Isolated MiBDI did not influence OS in patients with HCC after R0 resection. |
| first_indexed | 2024-03-09T01:32:10Z |
| format | Article |
| id | doaj.art-536a3da7bd8d4ba99c180d667944237d |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2025-03-21T15:10:57Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-536a3da7bd8d4ba99c180d667944237d2024-06-20T06:46:00ZengWileyCancer Medicine2045-76342023-11-011222208212082910.1002/cam4.6650Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter studyQizhen Huang0Kongying Lin1Zhipeng Lin2Hongbin Ji3Xiaoyu Zhou4Bin Wang5Yufeng Chen6Chuandong Sun7Shuguo Zheng8Jinhong Chen9Yifan Wang10Yanming Zhou11Weiping Zhou12Yongyi Zeng13Department of Radiation Oncology Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou ChinaDepartment of Hepatopancreatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou ChinaDepartment of Hepatopancreatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou ChinaDepartment of Radiation Oncology Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou ChinaThe School of Basic Medical Sciences Fujian Medical University Fuzhou ChinaThe School of Basic Medical Sciences Fujian Medical University Fuzhou ChinaDepartment of Hepatopancreatobiliary Surgery Zhangzhou Affiliated Hospital of Fujian Medical University Zhangzhou ChinaDepartment of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Qingdao University Qingdao ChinaInstitute of Hepatobiliary Surgery, Southwest Hospital Third Military Medical University Chongqing ChinaDepartment of General Surgery Huashan Hospital, Fudan University Shanghai ChinaDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University Hangzhou ChinaDepartment of Hepato‐Biliary‐Pancreato‐Vascular Surgery First Affiliated Hospital of Xiamen University Xiamen ChinaThe Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai ChinaDepartment of Hepatopancreatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou ChinaAbstract Objective To evaluate the prognostic significance of microscopic bile duct invasion (MiBDI) in hepatocellular carcinoma (HCC) following R0 resection. Patients and Methods Patients who underwent R0 resection for HCC at nine medical centers were stratified into five groups: neither bile duct nor vascular invasion (MiBDI−MVI−), microscopic bile duct invasion alone (MiBDI+MVI−), both microscopic bile duct and vascular invasion (MiBDI+MVI+), microscopic vascular invasion alone (MiBDI−MVI+), and macroscopic bile duct invasion (MaBDI). Overall survival (OS) was assessed using Kaplan–Meier analysis, and independent risk factors of OS were determined using Cox proportional hazards models. Results A total of 377 HCC cases were analyzed. The OS for MiBDI+MVI‐ was similar to that of MiBDI−MVI− (p > 0.05) but better than MiBDI+MVI+, MiBDI−MVI+, and MaBDI (all p < 0.05). Multivariate analysis indicated that MiBDI was not an independent risk factor for OS, while MVI and MaBDI were. Conclusions Overall survival (OS) in patients with MiBDI was superior to those with MVI and MaBDI. Isolated MiBDI did not influence OS in patients with HCC after R0 resection.https://doi.org/10.1002/cam4.6650bile duct invasionhepatocellular carcinomasurvivalvascular invasion |
| spellingShingle | Qizhen Huang Kongying Lin Zhipeng Lin Hongbin Ji Xiaoyu Zhou Bin Wang Yufeng Chen Chuandong Sun Shuguo Zheng Jinhong Chen Yifan Wang Yanming Zhou Weiping Zhou Yongyi Zeng Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study Cancer Medicine bile duct invasion hepatocellular carcinoma survival vascular invasion |
| title | Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study |
| title_full | Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study |
| title_fullStr | Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study |
| title_full_unstemmed | Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study |
| title_short | Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study |
| title_sort | prognosis value of microscopic bile duct invasion in hepatocellular carcinoma a multicenter study |
| topic | bile duct invasion hepatocellular carcinoma survival vascular invasion |
| url | https://doi.org/10.1002/cam4.6650 |
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