Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury
Abstract Considering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the search for new therapeutic approaches for it is in urgent demand. Mesenchymal stem cells (MSCs) have been increasingly recognized as a promising candidate for the treatment...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03351-2 |
| _version_ | 1797832218691764224 |
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| author | Zhangning Fu Yifan Zhang Xiaodong Geng Kun Chi Chao Liu Chengcheng Song Guangyan Cai Xiangmei Chen Quan Hong |
| author_facet | Zhangning Fu Yifan Zhang Xiaodong Geng Kun Chi Chao Liu Chengcheng Song Guangyan Cai Xiangmei Chen Quan Hong |
| author_sort | Zhangning Fu |
| collection | DOAJ |
| description | Abstract Considering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the search for new therapeutic approaches for it is in urgent demand. Mesenchymal stem cells (MSCs) have been increasingly recognized as a promising candidate for the treatment of AKI. However, clinical translation of MSCs-based therapies is hindered due to the poor retention and survival rates as well as the impaired paracrine ability of MSCs post-delivery. To address these issues, a series of strategies including local administration, three-dimensional culture, and preconditioning have been applied. Owing to the emergence and development of these novel biotechnologies, the effectiveness of MSCs in experimental AKI models is greatly improved. Here, we summarize the different approaches suggested to optimize the efficacy of MSCs therapy, aiming at promoting the therapeutic effects of MSCs on AKI patients. |
| first_indexed | 2024-04-09T14:04:17Z |
| format | Article |
| id | doaj.art-536a77f8fead405291ead486b6f18a0d |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T14:04:17Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-536a77f8fead405291ead486b6f18a0d2023-05-07T11:07:17ZengBMCStem Cell Research & Therapy1757-65122023-04-0114111610.1186/s13287-023-03351-2Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injuryZhangning Fu0Yifan Zhang1Xiaodong Geng2Kun Chi3Chao Liu4Chengcheng Song5Guangyan Cai6Xiangmei Chen7Quan Hong8Medical School of Chinese PLAMedical School of Chinese PLADepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese PLA, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease ResearchMedical School of Chinese PLADepartment of Critical Care Medicine, First Medical Center of Chinese PLA General HospitalDepartment of Nephrology, Beijing Electric Power HospitalDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese PLA, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease ResearchDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese PLA, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease ResearchDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese PLA, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease ResearchAbstract Considering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the search for new therapeutic approaches for it is in urgent demand. Mesenchymal stem cells (MSCs) have been increasingly recognized as a promising candidate for the treatment of AKI. However, clinical translation of MSCs-based therapies is hindered due to the poor retention and survival rates as well as the impaired paracrine ability of MSCs post-delivery. To address these issues, a series of strategies including local administration, three-dimensional culture, and preconditioning have been applied. Owing to the emergence and development of these novel biotechnologies, the effectiveness of MSCs in experimental AKI models is greatly improved. Here, we summarize the different approaches suggested to optimize the efficacy of MSCs therapy, aiming at promoting the therapeutic effects of MSCs on AKI patients.https://doi.org/10.1186/s13287-023-03351-2Mesenchymal stem cellsLocal administrationThree-dimensional culturePreconditioningAcute kidney injury |
| spellingShingle | Zhangning Fu Yifan Zhang Xiaodong Geng Kun Chi Chao Liu Chengcheng Song Guangyan Cai Xiangmei Chen Quan Hong Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury Stem Cell Research & Therapy Mesenchymal stem cells Local administration Three-dimensional culture Preconditioning Acute kidney injury |
| title | Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury |
| title_full | Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury |
| title_fullStr | Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury |
| title_full_unstemmed | Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury |
| title_short | Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury |
| title_sort | optimization strategies of mesenchymal stem cell based therapy for acute kidney injury |
| topic | Mesenchymal stem cells Local administration Three-dimensional culture Preconditioning Acute kidney injury |
| url | https://doi.org/10.1186/s13287-023-03351-2 |
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