Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
Introduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in the area of a previously implanted coronary stent. Understandin...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2023-01-01
|
Series: | Case Reports in Medicine |
Online Access: | http://dx.doi.org/10.1155/2023/3000420 |
_version_ | 1797903025460740096 |
---|---|
author | Gulnara Batenova Lyudmila Pivina Evgeny Dedov Altay Dyussupov Zhanar Zhumanbayeva Yerbol Smail Tatyana Belikhina Laura Pak Diana Ygiyeva |
author_facet | Gulnara Batenova Lyudmila Pivina Evgeny Dedov Altay Dyussupov Zhanar Zhumanbayeva Yerbol Smail Tatyana Belikhina Laura Pak Diana Ygiyeva |
author_sort | Gulnara Batenova |
collection | DOAJ |
description | Introduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in the area of a previously implanted coronary stent. Understanding the risk factors for stent thrombosis and restenosis is of particular importance in individuals at risk for adverse outcomes. The rarity of such situations makes the present study unique. Objective. Studying the peculiarities of restenosis and thrombosis of the coronary arteries in patients after coronavirus infection. Methods. The study was performed in the Department of Cardiovascular Surgery of Emergency Hospital, Semey City, in 2021. We have examined the medical records of 10 consecutive patients with restenosis of coronary arteries after coronavirus infection and 10 matched-by-age patients with similar restenosis of coronary arteries who did not have coronavirus infection as a comparison group. To determine statistically significant differences between independent samples, we calculated the Mann–Whitney U test. Results. The average age of patients was 65.7 years. Only one case was classified as early restenosis (within 8 days of previous revascularization), two cases represented late restenosis, and seven cases were very late restenoses. In 70% of cases, restenosis was localized in the left anterior descending artery, in 30% of cases, it was in the right coronary artery, and in 40% of cases, it was in the left circumflex artery. In comparison with patients who did not have a coronavirus infection, there were statistically significant differences regarding IgG (P<0.001) and fibrinogen (P=0.019). Conclusion. Patients with myocardial revascularization in the past have a higher risk of stent restenosis against the background of coronavirus infection due to excessive neointimal hyperplasia, hypercoagulability, increased inflammatory response, and endothelial dysfunction. |
first_indexed | 2024-04-10T09:26:26Z |
format | Article |
id | doaj.art-536ac61b5cad411fbc5db0c19de4c472 |
institution | Directory Open Access Journal |
issn | 1687-9635 |
language | English |
last_indexed | 2024-04-10T09:26:26Z |
publishDate | 2023-01-01 |
publisher | Hindawi Limited |
record_format | Article |
series | Case Reports in Medicine |
spelling | doaj.art-536ac61b5cad411fbc5db0c19de4c4722023-02-20T01:57:28ZengHindawi LimitedCase Reports in Medicine1687-96352023-01-01202310.1155/2023/3000420Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case SeriesGulnara Batenova0Lyudmila Pivina1Evgeny Dedov2Altay Dyussupov3Zhanar Zhumanbayeva4Yerbol Smail5Tatyana Belikhina6Laura Pak7Diana Ygiyeva8Semey Medical UniversitySemey Medical UniversityPirogov Russian National Research Medical UniversitySemey Medical UniversitySemey Medical UniversitySemey Medical UniversityCenter of Nuclear Medicine and OncologySemey Medical UniversitySemey Medical UniversityIntroduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in the area of a previously implanted coronary stent. Understanding the risk factors for stent thrombosis and restenosis is of particular importance in individuals at risk for adverse outcomes. The rarity of such situations makes the present study unique. Objective. Studying the peculiarities of restenosis and thrombosis of the coronary arteries in patients after coronavirus infection. Methods. The study was performed in the Department of Cardiovascular Surgery of Emergency Hospital, Semey City, in 2021. We have examined the medical records of 10 consecutive patients with restenosis of coronary arteries after coronavirus infection and 10 matched-by-age patients with similar restenosis of coronary arteries who did not have coronavirus infection as a comparison group. To determine statistically significant differences between independent samples, we calculated the Mann–Whitney U test. Results. The average age of patients was 65.7 years. Only one case was classified as early restenosis (within 8 days of previous revascularization), two cases represented late restenosis, and seven cases were very late restenoses. In 70% of cases, restenosis was localized in the left anterior descending artery, in 30% of cases, it was in the right coronary artery, and in 40% of cases, it was in the left circumflex artery. In comparison with patients who did not have a coronavirus infection, there were statistically significant differences regarding IgG (P<0.001) and fibrinogen (P=0.019). Conclusion. Patients with myocardial revascularization in the past have a higher risk of stent restenosis against the background of coronavirus infection due to excessive neointimal hyperplasia, hypercoagulability, increased inflammatory response, and endothelial dysfunction.http://dx.doi.org/10.1155/2023/3000420 |
spellingShingle | Gulnara Batenova Lyudmila Pivina Evgeny Dedov Altay Dyussupov Zhanar Zhumanbayeva Yerbol Smail Tatyana Belikhina Laura Pak Diana Ygiyeva Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series Case Reports in Medicine |
title | Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series |
title_full | Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series |
title_fullStr | Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series |
title_full_unstemmed | Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series |
title_short | Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series |
title_sort | restenosis of coronary arteries in patients with coronavirus infection case series |
url | http://dx.doi.org/10.1155/2023/3000420 |
work_keys_str_mv | AT gulnarabatenova restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT lyudmilapivina restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT evgenydedov restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT altaydyussupov restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT zhanarzhumanbayeva restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT yerbolsmail restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT tatyanabelikhina restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT laurapak restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries AT dianaygiyeva restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries |