Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series

Introduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in the area of a previously implanted coronary stent. Understandin...

Full description

Bibliographic Details
Main Authors: Gulnara Batenova, Lyudmila Pivina, Evgeny Dedov, Altay Dyussupov, Zhanar Zhumanbayeva, Yerbol Smail, Tatyana Belikhina, Laura Pak, Diana Ygiyeva
Format: Article
Language:English
Published: Hindawi Limited 2023-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2023/3000420
_version_ 1797903025460740096
author Gulnara Batenova
Lyudmila Pivina
Evgeny Dedov
Altay Dyussupov
Zhanar Zhumanbayeva
Yerbol Smail
Tatyana Belikhina
Laura Pak
Diana Ygiyeva
author_facet Gulnara Batenova
Lyudmila Pivina
Evgeny Dedov
Altay Dyussupov
Zhanar Zhumanbayeva
Yerbol Smail
Tatyana Belikhina
Laura Pak
Diana Ygiyeva
author_sort Gulnara Batenova
collection DOAJ
description Introduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in the area of a previously implanted coronary stent. Understanding the risk factors for stent thrombosis and restenosis is of particular importance in individuals at risk for adverse outcomes. The rarity of such situations makes the present study unique. Objective. Studying the peculiarities of restenosis and thrombosis of the coronary arteries in patients after coronavirus infection. Methods. The study was performed in the Department of Cardiovascular Surgery of Emergency Hospital, Semey City, in 2021. We have examined the medical records of 10 consecutive patients with restenosis of coronary arteries after coronavirus infection and 10 matched-by-age patients with similar restenosis of coronary arteries who did not have coronavirus infection as a comparison group. To determine statistically significant differences between independent samples, we calculated the Mann–Whitney U test. Results. The average age of patients was 65.7 years. Only one case was classified as early restenosis (within 8 days of previous revascularization), two cases represented late restenosis, and seven cases were very late restenoses. In 70% of cases, restenosis was localized in the left anterior descending artery, in 30% of cases, it was in the right coronary artery, and in 40% of cases, it was in the left circumflex artery. In comparison with patients who did not have a coronavirus infection, there were statistically significant differences regarding IgG (P<0.001) and fibrinogen (P=0.019). Conclusion. Patients with myocardial revascularization in the past have a higher risk of stent restenosis against the background of coronavirus infection due to excessive neointimal hyperplasia, hypercoagulability, increased inflammatory response, and endothelial dysfunction.
first_indexed 2024-04-10T09:26:26Z
format Article
id doaj.art-536ac61b5cad411fbc5db0c19de4c472
institution Directory Open Access Journal
issn 1687-9635
language English
last_indexed 2024-04-10T09:26:26Z
publishDate 2023-01-01
publisher Hindawi Limited
record_format Article
series Case Reports in Medicine
spelling doaj.art-536ac61b5cad411fbc5db0c19de4c4722023-02-20T01:57:28ZengHindawi LimitedCase Reports in Medicine1687-96352023-01-01202310.1155/2023/3000420Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case SeriesGulnara Batenova0Lyudmila Pivina1Evgeny Dedov2Altay Dyussupov3Zhanar Zhumanbayeva4Yerbol Smail5Tatyana Belikhina6Laura Pak7Diana Ygiyeva8Semey Medical UniversitySemey Medical UniversityPirogov Russian National Research Medical UniversitySemey Medical UniversitySemey Medical UniversitySemey Medical UniversityCenter of Nuclear Medicine and OncologySemey Medical UniversitySemey Medical UniversityIntroduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in the area of a previously implanted coronary stent. Understanding the risk factors for stent thrombosis and restenosis is of particular importance in individuals at risk for adverse outcomes. The rarity of such situations makes the present study unique. Objective. Studying the peculiarities of restenosis and thrombosis of the coronary arteries in patients after coronavirus infection. Methods. The study was performed in the Department of Cardiovascular Surgery of Emergency Hospital, Semey City, in 2021. We have examined the medical records of 10 consecutive patients with restenosis of coronary arteries after coronavirus infection and 10 matched-by-age patients with similar restenosis of coronary arteries who did not have coronavirus infection as a comparison group. To determine statistically significant differences between independent samples, we calculated the Mann–Whitney U test. Results. The average age of patients was 65.7 years. Only one case was classified as early restenosis (within 8 days of previous revascularization), two cases represented late restenosis, and seven cases were very late restenoses. In 70% of cases, restenosis was localized in the left anterior descending artery, in 30% of cases, it was in the right coronary artery, and in 40% of cases, it was in the left circumflex artery. In comparison with patients who did not have a coronavirus infection, there were statistically significant differences regarding IgG (P<0.001) and fibrinogen (P=0.019). Conclusion. Patients with myocardial revascularization in the past have a higher risk of stent restenosis against the background of coronavirus infection due to excessive neointimal hyperplasia, hypercoagulability, increased inflammatory response, and endothelial dysfunction.http://dx.doi.org/10.1155/2023/3000420
spellingShingle Gulnara Batenova
Lyudmila Pivina
Evgeny Dedov
Altay Dyussupov
Zhanar Zhumanbayeva
Yerbol Smail
Tatyana Belikhina
Laura Pak
Diana Ygiyeva
Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
Case Reports in Medicine
title Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
title_full Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
title_fullStr Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
title_full_unstemmed Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
title_short Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
title_sort restenosis of coronary arteries in patients with coronavirus infection case series
url http://dx.doi.org/10.1155/2023/3000420
work_keys_str_mv AT gulnarabatenova restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT lyudmilapivina restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT evgenydedov restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT altaydyussupov restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT zhanarzhumanbayeva restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT yerbolsmail restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT tatyanabelikhina restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT laurapak restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries
AT dianaygiyeva restenosisofcoronaryarteriesinpatientswithcoronavirusinfectioncaseseries