Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition
Pleomorphic adenoma (PA) is a localized tumor that presents pleomorphic or mixed characteristics of epithelial origin and is interwoven with mucoid tissue, myxoid tissue, and chondroid masses. The literature reported that PA most often occurs in adults aged 30–60 years and is a female predilection;...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/14/4210 |
| _version_ | 1797405962951196672 |
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| author | Yuka Matsumiya-Matsumoto Yoshihiro Morita Narikazu Uzawa |
| author_facet | Yuka Matsumiya-Matsumoto Yoshihiro Morita Narikazu Uzawa |
| author_sort | Yuka Matsumiya-Matsumoto |
| collection | DOAJ |
| description | Pleomorphic adenoma (PA) is a localized tumor that presents pleomorphic or mixed characteristics of epithelial origin and is interwoven with mucoid tissue, myxoid tissue, and chondroid masses. The literature reported that PA most often occurs in adults aged 30–60 years and is a female predilection; the exact etiology remains unclear. Epithelial–mesenchymal transition (EMT) is the transdifferentiation of stationary epithelial cells primarily activated by a core set of transcription factors (EMT-TFs) involved in DNA repair and offers advantages under various stress conditions. Data have suggested that EMTs represent the basic principle of tissue heterogeneity in PAs, demonstrating the potential of adult epithelial cells to transdifferentiate into mesenchymal cells. It has also been reported that multiple TFs, such as TWIST and SLUG, are involved in EMT in PA and that SLUG could play an essential role in the transition from myoepithelial to mesenchymal cells. Given this background, this review aims to summarize and clarify the involvement of EMT in the development of PA, chondrocyte differentiation, and malignant transformation to contribute to the fundamental elucidation of the mechanisms underlying EMT. |
| first_indexed | 2024-03-09T03:18:48Z |
| format | Article |
| id | doaj.art-536b2acd797d41eb90958f808f0d58e7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:18:48Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-536b2acd797d41eb90958f808f0d58e72023-12-03T15:13:54ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011114421010.3390/jcm11144210Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal TransitionYuka Matsumiya-Matsumoto0Yoshihiro Morita1Narikazu Uzawa2Department of Oral and Maxillofacial Surgery II, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita-shi 565-0871, Osaka, JapanDepartment of Oral and Maxillofacial Surgery II, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita-shi 565-0871, Osaka, JapanDepartment of Oral and Maxillofacial Surgery II, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita-shi 565-0871, Osaka, JapanPleomorphic adenoma (PA) is a localized tumor that presents pleomorphic or mixed characteristics of epithelial origin and is interwoven with mucoid tissue, myxoid tissue, and chondroid masses. The literature reported that PA most often occurs in adults aged 30–60 years and is a female predilection; the exact etiology remains unclear. Epithelial–mesenchymal transition (EMT) is the transdifferentiation of stationary epithelial cells primarily activated by a core set of transcription factors (EMT-TFs) involved in DNA repair and offers advantages under various stress conditions. Data have suggested that EMTs represent the basic principle of tissue heterogeneity in PAs, demonstrating the potential of adult epithelial cells to transdifferentiate into mesenchymal cells. It has also been reported that multiple TFs, such as TWIST and SLUG, are involved in EMT in PA and that SLUG could play an essential role in the transition from myoepithelial to mesenchymal cells. Given this background, this review aims to summarize and clarify the involvement of EMT in the development of PA, chondrocyte differentiation, and malignant transformation to contribute to the fundamental elucidation of the mechanisms underlying EMT.https://www.mdpi.com/2077-0383/11/14/4210pleomorphic adenomaepithelial–mesenchymal transitioncarcinoma ex-pleomorphic adenoma |
| spellingShingle | Yuka Matsumiya-Matsumoto Yoshihiro Morita Narikazu Uzawa Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition Journal of Clinical Medicine pleomorphic adenoma epithelial–mesenchymal transition carcinoma ex-pleomorphic adenoma |
| title | Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition |
| title_full | Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition |
| title_fullStr | Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition |
| title_full_unstemmed | Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition |
| title_short | Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition |
| title_sort | pleomorphic adenoma of the salivary glands and epithelial mesenchymal transition |
| topic | pleomorphic adenoma epithelial–mesenchymal transition carcinoma ex-pleomorphic adenoma |
| url | https://www.mdpi.com/2077-0383/11/14/4210 |
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