Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia
BackgroundPrevious studies showed that residents of higher elevations have lower glucose levels. Our objective in this study is to determine the basal and postprandial glucose levels in apparently healthy permanent residents of the miner population center of La Rinconada located 5100 meters (m) abov...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1387132/full |
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| author | Kely Melina Vilca Coaquira Kely Melina Vilca Coaquira Rossela Alejandra Rojas Chambilla Rossela Alejandra Rojas Chambilla Jeancarlo Tejada Flores Jeancarlo Tejada Flores Henry Oscar Tintaya Ramos Henry Oscar Tintaya Ramos Mariela Mercedes Quispe Trujillo Mariela Mercedes Quispe Trujillo Solanyela Anny Quispe Humpiri Solanyela Anny Quispe Humpiri Ángel Gabriel Calisaya Huacasi Ángel Gabriel Calisaya Huacasi Yony M. Pino Vanegas Gilberto Félix Peña Vicuña Alberto Alcibiades Salazar Granara Ana Lucia Tacuna Calderon Nancy Monica Garcia Bedoya Moua Yang Ivan Hancco Zirena Ivan Hancco Zirena |
| author_facet | Kely Melina Vilca Coaquira Kely Melina Vilca Coaquira Rossela Alejandra Rojas Chambilla Rossela Alejandra Rojas Chambilla Jeancarlo Tejada Flores Jeancarlo Tejada Flores Henry Oscar Tintaya Ramos Henry Oscar Tintaya Ramos Mariela Mercedes Quispe Trujillo Mariela Mercedes Quispe Trujillo Solanyela Anny Quispe Humpiri Solanyela Anny Quispe Humpiri Ángel Gabriel Calisaya Huacasi Ángel Gabriel Calisaya Huacasi Yony M. Pino Vanegas Gilberto Félix Peña Vicuña Alberto Alcibiades Salazar Granara Ana Lucia Tacuna Calderon Nancy Monica Garcia Bedoya Moua Yang Ivan Hancco Zirena Ivan Hancco Zirena |
| author_sort | Kely Melina Vilca Coaquira |
| collection | DOAJ |
| description | BackgroundPrevious studies showed that residents of higher elevations have lower glucose levels. Our objective in this study is to determine the basal and postprandial glucose levels in apparently healthy permanent residents of the miner population center of La Rinconada located 5100 meters (m) above sea level.MethodForty male permanent residents of the Rinconada miner population center were studied. The oral glucose tolerance test was used to evaluate basal and postprandial glycemia levels at 1, 2, and 3 h.ResultsThe individuals had a mean age of 43.95 ± 8.54 years. Basal glycemia in subjects without excessive erythrocytosis (EE) was 73.3 ± 7.9 mg/dL, while levels in patients with EE were 57.98 ± 7.38 mg/dL. In the postprandial period, at 1 h after oral glucose overload, a mean value of 76.35 ± 13.53 mg/dL was observed in subjects with EE compared to 94.68 ± 9.98 mg/dL in subjects without EE. After 2 h, subjects with EE had a glycemia level of 72.91 ± 9.17 mg/dL EE compared to 90.73 ± 13.86 mg/dL without EE. At 3 h, the average glycemia level in subjects with EE was 70.77 ± 8.73 mg/dL compared to 87.79 ± 14.16 mg/dL in those without EE.ConclusionThese findings suggest that under hypoxic conditions, glycemia levels are lower in both subjects with and without EE, having obtained lower levels in subjects with EE in relation to those with normal values of Hb and Hct. The results of this study indicate that in the conditions of severe hypoxia, blood glucose levels are below the values considered normal for sea level. |
| first_indexed | 2024-04-24T11:55:23Z |
| format | Article |
| id | doaj.art-536c1882adcb46bd8b73349ac3fa22e1 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-24T11:55:23Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-536c1882adcb46bd8b73349ac3fa22e12024-04-09T04:42:00ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-04-011510.3389/fphys.2024.13871321387132Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxiaKely Melina Vilca Coaquira0Kely Melina Vilca Coaquira1Rossela Alejandra Rojas Chambilla2Rossela Alejandra Rojas Chambilla3Jeancarlo Tejada Flores4Jeancarlo Tejada Flores5Henry Oscar Tintaya Ramos6Henry Oscar Tintaya Ramos7Mariela Mercedes Quispe Trujillo8Mariela Mercedes Quispe Trujillo9Solanyela Anny Quispe Humpiri10Solanyela Anny Quispe Humpiri11Ángel Gabriel Calisaya Huacasi12Ángel Gabriel Calisaya Huacasi13Yony M. Pino Vanegas14Gilberto Félix Peña Vicuña15Alberto Alcibiades Salazar Granara16Ana Lucia Tacuna Calderon17Nancy Monica Garcia Bedoya18Moua Yang19Ivan Hancco Zirena20Ivan Hancco Zirena21Facultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúACEM UNA, Puno, PerúFacultad De Educación, Escuela Profesional De Educación Física, UNA Puno, Puno, PerúFacultad de Medicina Humana, Universidad Nacional Del Altiplano, Puno, PerúInstituto De Investigación en Medicina De Altura (CIMA), Facultad De Medicina Humana, Universidad De San Martín De Porres, Lima, PerúInstituto De Investigación en Medicina De Altura (CIMA), Facultad De Medicina Humana, Universidad De San Martín De Porres, Lima, PerúFacultad De Ciencias De La Educación, Escuela Profesional De Educación Inicial, UNA Puno, Puno, PerúDivision of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesInstituto De Investigación en Medicina De Altura (CIMA), Facultad De Medicina Humana, Universidad De San Martín De Porres, Lima, PerúDivision of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesBackgroundPrevious studies showed that residents of higher elevations have lower glucose levels. Our objective in this study is to determine the basal and postprandial glucose levels in apparently healthy permanent residents of the miner population center of La Rinconada located 5100 meters (m) above sea level.MethodForty male permanent residents of the Rinconada miner population center were studied. The oral glucose tolerance test was used to evaluate basal and postprandial glycemia levels at 1, 2, and 3 h.ResultsThe individuals had a mean age of 43.95 ± 8.54 years. Basal glycemia in subjects without excessive erythrocytosis (EE) was 73.3 ± 7.9 mg/dL, while levels in patients with EE were 57.98 ± 7.38 mg/dL. In the postprandial period, at 1 h after oral glucose overload, a mean value of 76.35 ± 13.53 mg/dL was observed in subjects with EE compared to 94.68 ± 9.98 mg/dL in subjects without EE. After 2 h, subjects with EE had a glycemia level of 72.91 ± 9.17 mg/dL EE compared to 90.73 ± 13.86 mg/dL without EE. At 3 h, the average glycemia level in subjects with EE was 70.77 ± 8.73 mg/dL compared to 87.79 ± 14.16 mg/dL in those without EE.ConclusionThese findings suggest that under hypoxic conditions, glycemia levels are lower in both subjects with and without EE, having obtained lower levels in subjects with EE in relation to those with normal values of Hb and Hct. The results of this study indicate that in the conditions of severe hypoxia, blood glucose levels are below the values considered normal for sea level.https://www.frontiersin.org/articles/10.3389/fphys.2024.1387132/fullglucoseexcessive erythrocytosishypoxiaglucose tolerance testhigh altitude |
| spellingShingle | Kely Melina Vilca Coaquira Kely Melina Vilca Coaquira Rossela Alejandra Rojas Chambilla Rossela Alejandra Rojas Chambilla Jeancarlo Tejada Flores Jeancarlo Tejada Flores Henry Oscar Tintaya Ramos Henry Oscar Tintaya Ramos Mariela Mercedes Quispe Trujillo Mariela Mercedes Quispe Trujillo Solanyela Anny Quispe Humpiri Solanyela Anny Quispe Humpiri Ángel Gabriel Calisaya Huacasi Ángel Gabriel Calisaya Huacasi Yony M. Pino Vanegas Gilberto Félix Peña Vicuña Alberto Alcibiades Salazar Granara Ana Lucia Tacuna Calderon Nancy Monica Garcia Bedoya Moua Yang Ivan Hancco Zirena Ivan Hancco Zirena Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia Frontiers in Physiology glucose excessive erythrocytosis hypoxia glucose tolerance test high altitude |
| title | Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia |
| title_full | Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia |
| title_fullStr | Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia |
| title_full_unstemmed | Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia |
| title_short | Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia |
| title_sort | lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia |
| topic | glucose excessive erythrocytosis hypoxia glucose tolerance test high altitude |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1387132/full |
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