RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION
Aim. The evaluation of the prominence of subclinical nonspecific inflammation in men and women with ST-elevation myocardial infarction (STEMI) with different one year outcomes.Material and methods. Totally 223 patients with STEMI included — 56 (25,1%) women, 167 (74,9%) men. At 10-14 day of hospital...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2015-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/163 |
| _version_ | 1827063893865791488 |
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| author | E. V. Tavlueva O. L. Barbarash |
| author_facet | E. V. Tavlueva O. L. Barbarash |
| author_sort | E. V. Tavlueva |
| collection | DOAJ |
| description | Aim. The evaluation of the prominence of subclinical nonspecific inflammation in men and women with ST-elevation myocardial infarction (STEMI) with different one year outcomes.Material and methods. Totally 223 patients with STEMI included — 56 (25,1%) women, 167 (74,9%) men. At 10-14 day of hospitalization we checked inflammation factors: interleukins (IL) — 1а, 6, 8, 10, 12, С-reactive protein, tumor necrosis factor, neopterin. In the assessment of inflammatory reaction severity in men and women each group was assessed in general, and further was spread by the age: <65 y.o. and >65 y.o.Results. In assessment of the combination endpoint it was found that more significantly vascular events developed in women and made up 47% cases, but in men just 33% (р=0,001). Selecting the patients by age-relevant subgroups it was shown that in the age <65 y.o. women had more frequent vascular episodes, than men in this age: 50% (n=20) and 26% (n=89), respectively (р=0,000). In analysis of the IL-12 it is shown than women, comparing to men have this parameter higher in negative as in positive outcome: in positive prognosis 1,4 times higher (р=0,019), and negative prognosis — 1,6 times (р=0,045). In neopterine analysis, depending on combination endpoint it was found than in men with negative outcome the level of neopterin was significantly higher — 17,41 (9,52; 20,90) nmoles/L, than in men with positive outcome — 10,80 (6,53; 10,91) nmoles/L (р=0,000).Conclusion. Negative prognosis in women with STEMI is associated with the increase of IL-12 by 10-14 day, in men — neopterin. Key words: myocardial infarction, pro-inflammatory markers, gender specifics. |
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| id | doaj.art-536c36c6eab44b6c9b2665c89937cfa7 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:38:29Z |
| publishDate | 2015-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
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| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-536c36c6eab44b6c9b2665c89937cfa72024-10-17T12:21:34Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252015-10-01145353910.15829/1728-8800-2015-5-35-39163RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTIONE. V. Tavlueva0O. L. Barbarash1FSBSI "Scientific-Research Institute of Complex Cardiovascular Problems". Kemerovo, RussiaFSBSI "Scientific-Research Institute of Complex Cardiovascular Problems". Kemerovo, RussiaAim. The evaluation of the prominence of subclinical nonspecific inflammation in men and women with ST-elevation myocardial infarction (STEMI) with different one year outcomes.Material and methods. Totally 223 patients with STEMI included — 56 (25,1%) women, 167 (74,9%) men. At 10-14 day of hospitalization we checked inflammation factors: interleukins (IL) — 1а, 6, 8, 10, 12, С-reactive protein, tumor necrosis factor, neopterin. In the assessment of inflammatory reaction severity in men and women each group was assessed in general, and further was spread by the age: <65 y.o. and >65 y.o.Results. In assessment of the combination endpoint it was found that more significantly vascular events developed in women and made up 47% cases, but in men just 33% (р=0,001). Selecting the patients by age-relevant subgroups it was shown that in the age <65 y.o. women had more frequent vascular episodes, than men in this age: 50% (n=20) and 26% (n=89), respectively (р=0,000). In analysis of the IL-12 it is shown than women, comparing to men have this parameter higher in negative as in positive outcome: in positive prognosis 1,4 times higher (р=0,019), and negative prognosis — 1,6 times (р=0,045). In neopterine analysis, depending on combination endpoint it was found than in men with negative outcome the level of neopterin was significantly higher — 17,41 (9,52; 20,90) nmoles/L, than in men with positive outcome — 10,80 (6,53; 10,91) nmoles/L (р=0,000).Conclusion. Negative prognosis in women with STEMI is associated with the increase of IL-12 by 10-14 day, in men — neopterin. Key words: myocardial infarction, pro-inflammatory markers, gender specifics.https://cardiovascular.elpub.ru/jour/article/view/163инфаркт миокардапровоспалительные маркерыгендерные отличия |
| spellingShingle | E. V. Tavlueva O. L. Barbarash RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION Кардиоваскулярная терапия и профилактика инфаркт миокарда провоспалительные маркеры гендерные отличия |
| title | RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION |
| title_full | RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION |
| title_fullStr | RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION |
| title_full_unstemmed | RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION |
| title_short | RELATION OF PRO-INFLAMMATORY MARKERS IN MEN AND WOMEN WITH ONE YEAR OUTCOMES AFTER MYOCARDIAL INFARCTION |
| title_sort | relation of pro inflammatory markers in men and women with one year outcomes after myocardial infarction |
| topic | инфаркт миокарда провоспалительные маркеры гендерные отличия |
| url | https://cardiovascular.elpub.ru/jour/article/view/163 |
| work_keys_str_mv | AT evtavlueva relationofproinflammatorymarkersinmenandwomenwithoneyearoutcomesaftermyocardialinfarction AT olbarbarash relationofproinflammatorymarkersinmenandwomenwithoneyearoutcomesaftermyocardialinfarction |