Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice.
Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown. Morphological and functional alterations of retinal ganglion cells, the final output neurons of the vertebrate retina, are thought to be the major cause o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3777880?pdf=render |
| _version_ | 1818040450292908032 |
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| author | Jun Yu Lu Wang Shi-Jun Weng Xiong-Li Yang Dao-Qi Zhang Yong-Mei Zhong |
| author_facet | Jun Yu Lu Wang Shi-Jun Weng Xiong-Li Yang Dao-Qi Zhang Yong-Mei Zhong |
| author_sort | Jun Yu |
| collection | DOAJ |
| description | Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown. Morphological and functional alterations of retinal ganglion cells, the final output neurons of the vertebrate retina, are thought to be the major cause of visual defects in diabetes but direct evidence to support this notion is limited. In this study we investigated functional changes of retinal ganglion cells in a type 1-like diabetic mouse model. Our results demonstrated that the spontaneous spiking activity of ON-type retinal ganglion cells was increased in streptozotocin-diabetic mice after 3 to 4 months of diabetes. At this stage of diabetes, no apoptotic signals or cell loss were detected in the ganglion cell layer of the retina, suggesting that the functional alterations in ganglion cells occur prior to massive ganglion cell apoptosis. Furthermore, we found that the increased activity of ON-type ganglion cells was mainly a result of reduced inhibitory signaling to the cells in diabetes. This novel mechanism provides insight into how visual function is impaired in diabetic retinopathy. |
| first_indexed | 2024-12-10T08:14:43Z |
| format | Article |
| id | doaj.art-536f6fa582664117afc1015024e60e67 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T08:14:43Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-536f6fa582664117afc1015024e60e672022-12-22T01:56:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7604910.1371/journal.pone.0076049Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice.Jun YuLu WangShi-Jun WengXiong-Li YangDao-Qi ZhangYong-Mei ZhongImpairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown. Morphological and functional alterations of retinal ganglion cells, the final output neurons of the vertebrate retina, are thought to be the major cause of visual defects in diabetes but direct evidence to support this notion is limited. In this study we investigated functional changes of retinal ganglion cells in a type 1-like diabetic mouse model. Our results demonstrated that the spontaneous spiking activity of ON-type retinal ganglion cells was increased in streptozotocin-diabetic mice after 3 to 4 months of diabetes. At this stage of diabetes, no apoptotic signals or cell loss were detected in the ganglion cell layer of the retina, suggesting that the functional alterations in ganglion cells occur prior to massive ganglion cell apoptosis. Furthermore, we found that the increased activity of ON-type ganglion cells was mainly a result of reduced inhibitory signaling to the cells in diabetes. This novel mechanism provides insight into how visual function is impaired in diabetic retinopathy.http://europepmc.org/articles/PMC3777880?pdf=render |
| spellingShingle | Jun Yu Lu Wang Shi-Jun Weng Xiong-Li Yang Dao-Qi Zhang Yong-Mei Zhong Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. PLoS ONE |
| title | Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. |
| title_full | Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. |
| title_fullStr | Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. |
| title_full_unstemmed | Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. |
| title_short | Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. |
| title_sort | hyperactivity of on type retinal ganglion cells in streptozotocin induced diabetic mice |
| url | http://europepmc.org/articles/PMC3777880?pdf=render |
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