The Slowdown of Growth Rate Controls the Single-Cell Distribution of Biofilm Matrix Production via an SinI-SinR-SlrR Network

The Slowdown of Growth Rate Controls the Single-Cell Distribution of Biofilm Matrix Production via an SinI-SinR-SlrR Network

ABSTRACT In Bacillus subtilis, master regulator Spo0A controls several cell-differentiation pathways. Under moderate starvation, phosphorylated Spo0A (Spo0A~P) induces biofilm formation by indirectly activating genes controlling matrix production in a subpopulation of cells via an SinI-SinR-SlrR net...

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Bibliographic Details
Main Authors: Zhuo Chen, Brenda Zarazúa-Osorio, Priyanka Srivastava, Masaya Fujita, Oleg A. Igoshin
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mSystems
Subjects:
biofilms
biosystems
gene expression
stochasticity
Online Access:https://journals.asm.org/doi/10.1128/msystems.00622-22

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