Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography

Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography

SARS-CoV-2 emerged at the end of 2019 to cause an unprecedented pandemic of the deadly respiratory disease COVID-19 that continues to date. The viral main protease (Mpro) is essential for SARS-CoV-2 replication and is therefore an important drug target. Understanding the catalytic mechanism of Mpro,...

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Bibliographic Details
Main Authors: Daniel W. Kneller, Qiu Zhang, Leighton Coates, John M. Louis, Andrey Kovalevsky
Format: Article
Language:English
Published: International Union of Crystallography 2021-11-01
Series:IUCrJ
Subjects:
sars-cov-2
3cl protease
main protease
catalytic mechanism
c145a mutant
enzyme–substrate complex
room-temperature x-ray crystallography
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252521010113

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