Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

Abstract Background Upper motor neurons (UMNs) are a key component of motor neuron circuitry. Their degeneration is a hallmark for diseases, such as hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), and amyotrophic lateral sclerosis (ALS). Currently there are no preclinical assay...

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Bibliographic Details
Main Authors: Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, Gashaw M. Goshu, Nuran Koçak, Edward Xie, Richard B. Silverman, P. Hande Özdinler
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical and Translational Medicine
Subjects:
ALS
HSP
mSOD1
NU‐9
PLS
TDP‐43 pathology
Online Access:https://doi.org/10.1002/ctm2.336

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