The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study
ABSTRACT Amino acids are the building blocks of proteins, and sufficient protein intake is important for skeletal health. We utilized stored serum from the Cardiovascular Health Study in 1992–1993 to examine the relationship between levels of the essential amino acid tryptophan (trp) and its oxidize...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2023-10-01
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| Series: | JBMR Plus |
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| Online Access: | https://doi.org/10.1002/jbm4.10801 |
| _version_ | 1827162263596826624 |
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| author | Laura Carbone Petra Bůžková Howard A Fink John A Robbins Joshua I Barzilay Rachel E Elam Carlos Isales |
| author_facet | Laura Carbone Petra Bůžková Howard A Fink John A Robbins Joshua I Barzilay Rachel E Elam Carlos Isales |
| author_sort | Laura Carbone |
| collection | DOAJ |
| description | ABSTRACT Amino acids are the building blocks of proteins, and sufficient protein intake is important for skeletal health. We utilized stored serum from the Cardiovascular Health Study in 1992–1993 to examine the relationship between levels of the essential amino acid tryptophan (trp) and its oxidized and nonoxidized metabolites to risk for incident hip fractures and mortality over 12 years of follow‐up. We included 131 persons who sustained a hip fracture during this time period and 131 without a hip fracture over these same 12 years of follow‐up; 58% female and 95% White. Weighted multivariable Cox hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of incident hip fracture associated with a one standard deviation (SD) higher trp or its metabolites exposure. Relative risk regression was used to evaluate the cross‐sectional association of trp and its metabolites with frailty. Higher serum levels of trp were significantly associated with lower risk of incident hip fractures (HR = 0.75 per SD of trp (95% CI 0.57–0.99) but were not significantly associated with mortality or frailty status by Freid's frailty index. There were no statistically significant associations between any of the oxidized or nonoxidized products of trp with incident hip fractures (p ≥ 0.64), mortality (p ≥ 0.20), or cross‐sectional frailty status (p ≥ 0.13) after multiple testing adjustment. Randomized clinical trials examining whether increasing trp intake is beneficial for osteoporosis are needed. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. |
| first_indexed | 2024-03-11T19:43:20Z |
| format | Article |
| id | doaj.art-537127dbb83740bebcfa59254c8ab7cf |
| institution | Directory Open Access Journal |
| issn | 2473-4039 |
| language | English |
| last_indexed | 2025-03-21T00:42:02Z |
| publishDate | 2023-10-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | JBMR Plus |
| spelling | doaj.art-537127dbb83740bebcfa59254c8ab7cf2024-08-03T06:08:31ZengOxford University PressJBMR Plus2473-40392023-10-01710n/an/a10.1002/jbm4.10801The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health StudyLaura Carbone0Petra Bůžková1Howard A Fink2John A Robbins3Joshua I Barzilay4Rachel E Elam5Carlos Isales6Division of Rheumatology, Department of Medicine Augusta University Augusta GA USADepartment of Biostatistics University of Washington Seattle WA USAGeriatric Research Education and Clinical Center Veterans Affairs Health Care System Minneapolis MN USADepartment of Medicine University of California Davis Davis CA USADivision of Endocrinology, Kaiser Permanente of Georgia Emory University School of Medicine Atlanta GA USADivision of Rheumatology, Department of Medicine Augusta University Augusta GA USACharlie Norwood Veterans Affairs Medical Center Veterans Affairs Health Care System Augusta GA USAABSTRACT Amino acids are the building blocks of proteins, and sufficient protein intake is important for skeletal health. We utilized stored serum from the Cardiovascular Health Study in 1992–1993 to examine the relationship between levels of the essential amino acid tryptophan (trp) and its oxidized and nonoxidized metabolites to risk for incident hip fractures and mortality over 12 years of follow‐up. We included 131 persons who sustained a hip fracture during this time period and 131 without a hip fracture over these same 12 years of follow‐up; 58% female and 95% White. Weighted multivariable Cox hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of incident hip fracture associated with a one standard deviation (SD) higher trp or its metabolites exposure. Relative risk regression was used to evaluate the cross‐sectional association of trp and its metabolites with frailty. Higher serum levels of trp were significantly associated with lower risk of incident hip fractures (HR = 0.75 per SD of trp (95% CI 0.57–0.99) but were not significantly associated with mortality or frailty status by Freid's frailty index. There were no statistically significant associations between any of the oxidized or nonoxidized products of trp with incident hip fractures (p ≥ 0.64), mortality (p ≥ 0.20), or cross‐sectional frailty status (p ≥ 0.13) after multiple testing adjustment. Randomized clinical trials examining whether increasing trp intake is beneficial for osteoporosis are needed. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.https://doi.org/10.1002/jbm4.10801AGINGFRACTURE PREVENTIONGENERAL POPULATION STUDIESOSTEOPOROSISSTATISTICAL METHODS |
| spellingShingle | Laura Carbone Petra Bůžková Howard A Fink John A Robbins Joshua I Barzilay Rachel E Elam Carlos Isales The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study JBMR Plus AGING FRACTURE PREVENTION GENERAL POPULATION STUDIES OSTEOPOROSIS STATISTICAL METHODS |
| title | The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study |
| title_full | The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study |
| title_fullStr | The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study |
| title_full_unstemmed | The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study |
| title_short | The Association of Tryptophan and Its Metabolites With Incident Hip Fractures, Mortality, and Prevalent Frailty in Older Adults: The Cardiovascular Health Study |
| title_sort | association of tryptophan and its metabolites with incident hip fractures mortality and prevalent frailty in older adults the cardiovascular health study |
| topic | AGING FRACTURE PREVENTION GENERAL POPULATION STUDIES OSTEOPOROSIS STATISTICAL METHODS |
| url | https://doi.org/10.1002/jbm4.10801 |
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