Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown.Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12),...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.946402/full |
| _version_ | 1811277561808814080 |
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| author | Anamei Silva-Reis Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Thiago Gibson Gonçalves-Alves Victor Hugo Souza-Palmeira Helida Cristina Aquino-Santos Andre Luis Lacerda Bachi Luis Vicente Franco de Oliveira Rodrigo Álvaro Brandão Lopes-Martins Iranse Oliveira-Silva Regiane Albertini Claudio Ricardo Frison Rodolfo P Vieira Rodolfo P Vieira |
| author_facet | Anamei Silva-Reis Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Thiago Gibson Gonçalves-Alves Victor Hugo Souza-Palmeira Helida Cristina Aquino-Santos Andre Luis Lacerda Bachi Luis Vicente Franco de Oliveira Rodrigo Álvaro Brandão Lopes-Martins Iranse Oliveira-Silva Regiane Albertini Claudio Ricardo Frison Rodolfo P Vieira Rodolfo P Vieira |
| author_sort | Anamei Silva-Reis |
| collection | DOAJ |
| description | Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown.Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate.Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz–R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups.Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1. |
| first_indexed | 2024-04-13T00:19:00Z |
| format | Article |
| id | doaj.art-53723d5820374956a82bcadc9f8af6a8 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T00:19:00Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-53723d5820374956a82bcadc9f8af6a82022-12-22T03:10:51ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-09-011310.3389/fphys.2022.946402946402Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese womenAnamei Silva-Reis0Maysa Alves Rodrigues Brandao-Rangel1Renilson Moraes-Ferreira2Thiago Gibson Gonçalves-Alves3Victor Hugo Souza-Palmeira4Helida Cristina Aquino-Santos5Andre Luis Lacerda Bachi6Luis Vicente Franco de Oliveira7Rodrigo Álvaro Brandão Lopes-Martins8Iranse Oliveira-Silva9Regiane Albertini10Claudio Ricardo Frison11Rodolfo P Vieira12Rodolfo P Vieira13Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Health Science, University of Santo Amaro, São Paulo, BrazilPost-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, BrazilPost-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, BrazilPost-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, BrazilPost-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, BrazilBackground: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown.Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate.Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz–R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups.Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1.https://www.frontiersin.org/articles/10.3389/fphys.2022.946402/fullexercise immunologylungoverweightobesityphysical trainingpulmonary inflammation and fibrosis |
| spellingShingle | Anamei Silva-Reis Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Thiago Gibson Gonçalves-Alves Victor Hugo Souza-Palmeira Helida Cristina Aquino-Santos Andre Luis Lacerda Bachi Luis Vicente Franco de Oliveira Rodrigo Álvaro Brandão Lopes-Martins Iranse Oliveira-Silva Regiane Albertini Claudio Ricardo Frison Rodolfo P Vieira Rodolfo P Vieira Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women Frontiers in Physiology exercise immunology lung overweight obesity physical training pulmonary inflammation and fibrosis |
| title | Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women |
| title_full | Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women |
| title_fullStr | Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women |
| title_full_unstemmed | Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women |
| title_short | Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women |
| title_sort | combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women |
| topic | exercise immunology lung overweight obesity physical training pulmonary inflammation and fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.946402/full |
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