Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas
Lead (Pb) is an environmental pollutant which may cause harmful effects on human health. It may be present within the mud-packs deposed on patient'skin for treating some rheumatologic conditions. We aimed to evaluate the diffusion of Pb from therapeutic mud-packs toward the human body in order...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Environmental Chemistry and Ecotoxicology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590182623000164 |
| _version_ | 1797385083440594944 |
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| author | Karine Dubourg Sébastien Labarthe Jérôme Dimet Frédéric Bauduer |
| author_facet | Karine Dubourg Sébastien Labarthe Jérôme Dimet Frédéric Bauduer |
| author_sort | Karine Dubourg |
| collection | DOAJ |
| description | Lead (Pb) is an environmental pollutant which may cause harmful effects on human health. It may be present within the mud-packs deposed on patient'skin for treating some rheumatologic conditions. We aimed to evaluate the diffusion of Pb from therapeutic mud-packs toward the human body in order to exclude safety concerns.We quantified Pb using inductively-coupled plasma mass spectrometry in blood (erythrocytes) and urine (raw concentration and divided by creatinine concentration) of 35 young healthy volunteers before and after the 21-day pelotherapy procedure from French medical spas (i.e hot micro-perforated polyethylene bags embedded-mud packs soaked in mineral water and deposed during 10 min on five cutaneous sites, in 5-day sequences during 3 consecutive weeks). We did not evidence a significant increase in their erythrocyte (p: 0.89) or urine (p: 0.96) concentrations when comparing pre- and post-treatment samples by the bilateral apparied Student test. These levels were markedly inferior to the recommended cut-off in all our participants taking into account the exclusion of individuals with extreme urinary creatinine values. From our sample including individuals with an optimal transcutaneous diffusion capacity (young persons with low subcutaneous fat mass) we conclude that there is no risk of Pb overexposure in patients receiving this type of pelotherapy regimen. |
| first_indexed | 2024-03-08T21:49:02Z |
| format | Article |
| id | doaj.art-53737433fcbb42fcb7d1021b3227ae45 |
| institution | Directory Open Access Journal |
| issn | 2590-1826 |
| language | English |
| last_indexed | 2024-03-08T21:49:02Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Environmental Chemistry and Ecotoxicology |
| spelling | doaj.art-53737433fcbb42fcb7d1021b3227ae452023-12-20T07:36:37ZengKeAi Communications Co., Ltd.Environmental Chemistry and Ecotoxicology2590-18262023-01-015186192Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spasKarine Dubourg0Sébastien Labarthe1Jérôme Dimet2Frédéric Bauduer3Institut du Thermalisme, Université de Bordeaux, Collège des sciences de la santé, 40100 Dax, FranceInstitut du Thermalisme, Université de Bordeaux, Collège des sciences de la santé, 40100 Dax, FranceService de Recherche Clinique, Groupement Hospitalier Territorial des Landes, 40000 Mont-de-Marsan, FranceInstitut du Thermalisme, Université de Bordeaux, Collège des sciences de la santé, 40100 Dax, France; Corresponding author at: Institut du Thermalisme, Université de Bordeaux, 8 rue Sainte Ursule, 40100 Dax, France.Lead (Pb) is an environmental pollutant which may cause harmful effects on human health. It may be present within the mud-packs deposed on patient'skin for treating some rheumatologic conditions. We aimed to evaluate the diffusion of Pb from therapeutic mud-packs toward the human body in order to exclude safety concerns.We quantified Pb using inductively-coupled plasma mass spectrometry in blood (erythrocytes) and urine (raw concentration and divided by creatinine concentration) of 35 young healthy volunteers before and after the 21-day pelotherapy procedure from French medical spas (i.e hot micro-perforated polyethylene bags embedded-mud packs soaked in mineral water and deposed during 10 min on five cutaneous sites, in 5-day sequences during 3 consecutive weeks). We did not evidence a significant increase in their erythrocyte (p: 0.89) or urine (p: 0.96) concentrations when comparing pre- and post-treatment samples by the bilateral apparied Student test. These levels were markedly inferior to the recommended cut-off in all our participants taking into account the exclusion of individuals with extreme urinary creatinine values. From our sample including individuals with an optimal transcutaneous diffusion capacity (young persons with low subcutaneous fat mass) we conclude that there is no risk of Pb overexposure in patients receiving this type of pelotherapy regimen.http://www.sciencedirect.com/science/article/pii/S2590182623000164LeadpelotherapyMud packsEnvironmental health |
| spellingShingle | Karine Dubourg Sébastien Labarthe Jérôme Dimet Frédéric Bauduer Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas Environmental Chemistry and Ecotoxicology Lead pelotherapy Mud packs Environmental health |
| title | Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas |
| title_full | Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas |
| title_fullStr | Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas |
| title_full_unstemmed | Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas |
| title_short | Evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro-perforated polyethylene bags according to the protocol used in French medical spas |
| title_sort | evolution of erythrocyte and urine lead concentrations after cutaneous exposure to mud packs embedded into micro perforated polyethylene bags according to the protocol used in french medical spas |
| topic | Lead pelotherapy Mud packs Environmental health |
| url | http://www.sciencedirect.com/science/article/pii/S2590182623000164 |
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