Synthesis and biological evaluation of 18F-labelled deuterated tropane derivatives as dopamine transporter probes

Synthesis and biological evaluation of 18F-labelled deuterated tropane derivatives as dopamine transporter probes

Purpose: Dopamine transporter (DAT) is a promising target for positron emission tomography (PET) imaging of many neuropsychiatric diseases. 18F-labelled N-alkyl tropane analogues were reported to be useful PET radioligands for DAT. However, the drawback of 18F-labelled tropane analogues is that N-al...

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Bibliographic Details
Main Authors:	Qianyue Hu, Qingming Li, Jie Tang, Jie Liu, Yi Fang, Chunyi Liu, Meihui Qi, Zhengping Chen
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Series:	Arabian Journal of Chemistry
Subjects:	Dopamine transporter PET Deuterium 18F-labelling Tropane In vivo metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535223007402

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