The Zn(II)-1,4,7-Trimethyl-1,4,7-Triazacyclononane Complex: A Monometallic Catalyst Active in Two Protonation States

The Zn(II)-1,4,7-Trimethyl-1,4,7-Triazacyclononane Complex: A Monometallic Catalyst Active in Two Protonation States

In this paper, the unusual reactivity of the complex Zn(II)-1,4,7-trimethyl-1, 4,7-triazacyclononane (2) in the transesterification of the RNA-model substrate, HPNP (3), is reported. The dependence of the reactivity (k2) with pH does not follow the characteristic bell-shape profile typical of comple...

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Bibliographic Details
Main Authors: Marta Diez-Castellnou, Giovanni Salassa, Fabrizio Mancin, Paolo Scrimin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Chemistry
Subjects:
RNA
monometallic Zn(II)-complexes
azacrown
phosphate cleavage
phosphoesterase models
kinetics
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00469/full

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