Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209417/?tool=EBI |
| _version_ | 1818403959718543360 |
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| author | John S Cho Yi Guo Romela Irene Ramos Frank Hebroni Seema B Plaisier Caiyun Xuan Jennifer L Granick Hironori Matsushima Akira Takashima Yoichiro Iwakura Ambrose L Cheung Genhong Cheng Delphine J Lee Scott I Simon Lloyd S Miller |
| author_facet | John S Cho Yi Guo Romela Irene Ramos Frank Hebroni Seema B Plaisier Caiyun Xuan Jennifer L Granick Hironori Matsushima Akira Takashima Yoichiro Iwakura Ambrose L Cheung Genhong Cheng Delphine J Lee Scott I Simon Lloyd S Miller |
| author_sort | John S Cho |
| collection | DOAJ |
| description | Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the S. aureus infection revealed a strong functional and temporal association between neutrophil recruitment and IL-1β/IL-1R activation. Unexpectedly, neutrophils but not monocytes/macrophages or other MHCII-expressing antigen presenting cells were the predominant source of IL-1β at the site of infection. Furthermore, neutrophil-derived IL-1β was essential for host defense since adoptive transfer of IL-1β-expressing neutrophils was sufficient to restore the impaired neutrophil abscess formation in S. aureus-infected IL-1β-deficient mice. S. aureus-induced IL-1β production by neutrophils required TLR2, NOD2, FPR1 and the ASC/NLRP3 inflammasome in an α-toxin-dependent mechanism. Taken together, IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1β production by neutrophils. |
| first_indexed | 2024-12-14T08:32:33Z |
| format | Article |
| id | doaj.art-537606f4a0f84c01b78748202198eeae |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-14T08:32:33Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-537606f4a0f84c01b78748202198eeae2022-12-21T23:09:29ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-01811e100304710.1371/journal.ppat.1003047Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.John S ChoYi GuoRomela Irene RamosFrank HebroniSeema B PlaisierCaiyun XuanJennifer L GranickHironori MatsushimaAkira TakashimaYoichiro IwakuraAmbrose L CheungGenhong ChengDelphine J LeeScott I SimonLloyd S MillerNeutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis and in vivo multispectral noninvasive imaging during the S. aureus infection revealed a strong functional and temporal association between neutrophil recruitment and IL-1β/IL-1R activation. Unexpectedly, neutrophils but not monocytes/macrophages or other MHCII-expressing antigen presenting cells were the predominant source of IL-1β at the site of infection. Furthermore, neutrophil-derived IL-1β was essential for host defense since adoptive transfer of IL-1β-expressing neutrophils was sufficient to restore the impaired neutrophil abscess formation in S. aureus-infected IL-1β-deficient mice. S. aureus-induced IL-1β production by neutrophils required TLR2, NOD2, FPR1 and the ASC/NLRP3 inflammasome in an α-toxin-dependent mechanism. Taken together, IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1β production by neutrophils.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209417/?tool=EBI |
| spellingShingle | John S Cho Yi Guo Romela Irene Ramos Frank Hebroni Seema B Plaisier Caiyun Xuan Jennifer L Granick Hironori Matsushima Akira Takashima Yoichiro Iwakura Ambrose L Cheung Genhong Cheng Delphine J Lee Scott I Simon Lloyd S Miller Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathogens |
| title | Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. |
| title_full | Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. |
| title_fullStr | Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. |
| title_full_unstemmed | Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. |
| title_short | Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. |
| title_sort | neutrophil derived il 1β is sufficient for abscess formation in immunity against staphylococcus aureus in mice |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209417/?tool=EBI |
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