Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review

Abstract Objective: To investigate progressive non-fluent aphasia and histopathologically-proven corticobasal degeneration. Methods: We evaluated symptoms, signs, neuropsychological deficits, and radiology data longitudinally, in a patient with autopsy-proven corticobasal degeneration and correlat...

Full description

Bibliographic Details
Main Authors: Paulo Roberto de Brito-Marques, Roberto José Vieira-Mello, Luciano Montenegro, Maria de Fátima Vasco Aragão
Format: Article
Language:English
Published: Associação Neurologia Cognitiva e do Comportamento
Series:Dementia & Neuropsychologia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000200135&lng=en&tlng=en
_version_ 1818205387209310208
author Paulo Roberto de Brito-Marques
Roberto José Vieira-Mello
Luciano Montenegro
Maria de Fátima Vasco Aragão
author_facet Paulo Roberto de Brito-Marques
Roberto José Vieira-Mello
Luciano Montenegro
Maria de Fátima Vasco Aragão
author_sort Paulo Roberto de Brito-Marques
collection DOAJ
description Abstract Objective: To investigate progressive non-fluent aphasia and histopathologically-proven corticobasal degeneration. Methods: We evaluated symptoms, signs, neuropsychological deficits, and radiology data longitudinally, in a patient with autopsy-proven corticobasal degeneration and correlated these observations directly to the neuroanatomic distribution of the disease. Results: At presentation, a specific pattern of cognitive impairment was evident with an extreme extrapyramidal motor abnormality. Follow-up examination revealed persistent impairment of praxis and executive functioning, progressive worsening of language performance, and moderately preserved memory. The motor disorder manifested and worsened as the condition progressed. Many of the residual nerve cells were ballooned and achromatic with eccentric nuclei. Tau-immunoreactive pathology was significantly more prominent in neurons in the frontal and parietal cortices and dentate nuclei than in temporal neocortex, hippocampi and brainstem. Conclusion: The clinical diagnosis of progressive non-fluent aphasia secondary to corticobasal degeneration hinged on a specific pattern of impaired cognition as well as an extrapyramidal motor disorder, reflecting the neuroanatomic distribution of the disease in frontal and anterior temporal cortices and the dentate nuclei.
first_indexed 2024-12-12T03:56:19Z
format Article
id doaj.art-537a4f3d20c64959b65b5cb808d232c4
institution Directory Open Access Journal
issn 1980-5764
language English
last_indexed 2024-12-12T03:56:19Z
publisher Associação Neurologia Cognitiva e do Comportamento
record_format Article
series Dementia & Neuropsychologia
spelling doaj.art-537a4f3d20c64959b65b5cb808d232c42022-12-22T00:39:14ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57645213514110.1590/S1980-57642011DN05020013S1980-57642011000200135Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and reviewPaulo Roberto de Brito-MarquesRoberto José Vieira-MelloLuciano MontenegroMaria de Fátima Vasco AragãoAbstract Objective: To investigate progressive non-fluent aphasia and histopathologically-proven corticobasal degeneration. Methods: We evaluated symptoms, signs, neuropsychological deficits, and radiology data longitudinally, in a patient with autopsy-proven corticobasal degeneration and correlated these observations directly to the neuroanatomic distribution of the disease. Results: At presentation, a specific pattern of cognitive impairment was evident with an extreme extrapyramidal motor abnormality. Follow-up examination revealed persistent impairment of praxis and executive functioning, progressive worsening of language performance, and moderately preserved memory. The motor disorder manifested and worsened as the condition progressed. Many of the residual nerve cells were ballooned and achromatic with eccentric nuclei. Tau-immunoreactive pathology was significantly more prominent in neurons in the frontal and parietal cortices and dentate nuclei than in temporal neocortex, hippocampi and brainstem. Conclusion: The clinical diagnosis of progressive non-fluent aphasia secondary to corticobasal degeneration hinged on a specific pattern of impaired cognition as well as an extrapyramidal motor disorder, reflecting the neuroanatomic distribution of the disease in frontal and anterior temporal cortices and the dentate nuclei.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000200135&lng=en&tlng=enprogressive non-fluent aphasianeuropsychologyneuroimagingneuropathologyand corticobasal degeneration.
spellingShingle Paulo Roberto de Brito-Marques
Roberto José Vieira-Mello
Luciano Montenegro
Maria de Fátima Vasco Aragão
Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review
Dementia & Neuropsychologia
progressive non-fluent aphasia
neuropsychology
neuroimaging
neuropathology
and corticobasal degeneration.
title Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review
title_full Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review
title_fullStr Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review
title_full_unstemmed Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review
title_short Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review
title_sort clinicopathologic analysis of progressive non fluent aphasia and corticobasal degeneration case report and review
topic progressive non-fluent aphasia
neuropsychology
neuroimaging
neuropathology
and corticobasal degeneration.
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000200135&lng=en&tlng=en
work_keys_str_mv AT paulorobertodebritomarques clinicopathologicanalysisofprogressivenonfluentaphasiaandcorticobasaldegenerationcasereportandreview
AT robertojosevieiramello clinicopathologicanalysisofprogressivenonfluentaphasiaandcorticobasaldegenerationcasereportandreview
AT lucianomontenegro clinicopathologicanalysisofprogressivenonfluentaphasiaandcorticobasaldegenerationcasereportandreview
AT mariadefatimavascoaragao clinicopathologicanalysisofprogressivenonfluentaphasiaandcorticobasaldegenerationcasereportandreview