The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations

The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations

Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of response (CFR) for various dosing regimens of caspofungin in all pa...

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Bibliographic Details
Main Authors: Qianting Yang, Tao Zhang, Ying Zhang, Dan Sun, Xiaowei Zheng, Qian Du, Xue Wang, Xiaoliang Cheng, Jianfeng Xing, Yalin Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
caspofungin
population pharmacokinetics
intensive care unit
body weight
hypoalbuminaemia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.993330/full

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