Epigenetics of suicidal behavior
Suicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of thi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2019-08-01
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| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/2212 |
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| author | R. N. Mustafin A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova S. B. Malykh V. V. Viktorov E. K. Khusnutdinova |
| author_facet | R. N. Mustafin A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova S. B. Malykh V. V. Viktorov E. K. Khusnutdinova |
| author_sort | R. N. Mustafin |
| collection | DOAJ |
| description | Suicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of this pathology. The role of hereditary factors in the development of suicidal behavior is estimated at 30–55 %, with a pronounced comorbidity with other psychopathologies. The study of genetic liability to suicidal behavior is based on molecular-genetic methods including association and linkage analyses, chip gene expression arrays, and genome-wide association studies. Published data identified multiple genes including those involved in the functioning of serotonergic (SLC6A4, TPH, 5-HT1A), hypothalamic-pituitary-adrenal systems (FKBP5) and polyamines (SAT and OATL1) associated with suicidal behavior. However, the diversity of interacting genetic loci complicates the interpretation of the development of a complex phenotype of pathology and prevents the association from being detected. To solve this problem and interpret the missing relationship between the environment and the genome, promising results were obtained from a study of epigenetic factors, which affected the expression of a number of candidate genes involved in brain functioning in suicidal behavior. The analysis of a brain obtained from suicide victims, representing a unique tool for the analysis of modified genomic processes, revealed a wide range of reprogramming patterns of DNA methylation in promoters of the genes of polyamine (OAZ1, OAZ2, AMD1, ARG2, SKA2), serotonergic (SLC6A4) and GABAergic (GABRA1) systems, HPA-axis (GR, NR3C1), tyrosine kinase (TrkB) receptors, brain-derived neurotrophic factor (BDNF). The role of histone modifications in distinct genes (Cx30, Cx43, TrkB.T1) and the expression of specific long noncoding RNAs and microRNAs in the development of suicidal behavior, which is promising for the development of diagnostic algorithms and target therapy, is discussed. |
| first_indexed | 2024-03-07T16:05:57Z |
| format | Article |
| id | doaj.art-537b5a2d295041c5b81ff3b284f014d2 |
| institution | Directory Open Access Journal |
| issn | 2500-3259 |
| language | English |
| last_indexed | 2024-04-24T11:07:16Z |
| publishDate | 2019-08-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj.art-537b5a2d295041c5b81ff3b284f014d22024-04-11T15:31:01ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592019-08-0123560060710.18699/VJ19.531949Epigenetics of suicidal behaviorR. N. Mustafin0A. V. Kazantseva1R. F. Enikeeva2Yu. D. Davydova3S. B. Malykh4V. V. Viktorov5E. K. Khusnutdinova6Bashkir State Medical University; Bashkir State UniversityInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASBashkir State University; Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASPsychological Institute of the Russian Academy of EducationBashkir State Medical UniversityBashkir State Medical University; Bashkir State University; Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASSuicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of this pathology. The role of hereditary factors in the development of suicidal behavior is estimated at 30–55 %, with a pronounced comorbidity with other psychopathologies. The study of genetic liability to suicidal behavior is based on molecular-genetic methods including association and linkage analyses, chip gene expression arrays, and genome-wide association studies. Published data identified multiple genes including those involved in the functioning of serotonergic (SLC6A4, TPH, 5-HT1A), hypothalamic-pituitary-adrenal systems (FKBP5) and polyamines (SAT and OATL1) associated with suicidal behavior. However, the diversity of interacting genetic loci complicates the interpretation of the development of a complex phenotype of pathology and prevents the association from being detected. To solve this problem and interpret the missing relationship between the environment and the genome, promising results were obtained from a study of epigenetic factors, which affected the expression of a number of candidate genes involved in brain functioning in suicidal behavior. The analysis of a brain obtained from suicide victims, representing a unique tool for the analysis of modified genomic processes, revealed a wide range of reprogramming patterns of DNA methylation in promoters of the genes of polyamine (OAZ1, OAZ2, AMD1, ARG2, SKA2), serotonergic (SLC6A4) and GABAergic (GABRA1) systems, HPA-axis (GR, NR3C1), tyrosine kinase (TrkB) receptors, brain-derived neurotrophic factor (BDNF). The role of histone modifications in distinct genes (Cx30, Cx43, TrkB.T1) and the expression of specific long noncoding RNAs and microRNAs in the development of suicidal behavior, which is promising for the development of diagnostic algorithms and target therapy, is discussed.https://vavilov.elpub.ru/jour/article/view/2212associationbrainmethylationnon-coding rnassuicideepigenetics |
| spellingShingle | R. N. Mustafin A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova S. B. Malykh V. V. Viktorov E. K. Khusnutdinova Epigenetics of suicidal behavior Вавиловский журнал генетики и селекции association brain methylation non-coding rnas suicide epigenetics |
| title | Epigenetics of suicidal behavior |
| title_full | Epigenetics of suicidal behavior |
| title_fullStr | Epigenetics of suicidal behavior |
| title_full_unstemmed | Epigenetics of suicidal behavior |
| title_short | Epigenetics of suicidal behavior |
| title_sort | epigenetics of suicidal behavior |
| topic | association brain methylation non-coding rnas suicide epigenetics |
| url | https://vavilov.elpub.ru/jour/article/view/2212 |
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