Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

<b>Background/Objectives:</b> This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability. Additionally, the study e...

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Autors principals: Rasha M. Elkanayati, Indrajeet Karnik, Prateek Uttreja, Nagarjuna Narala, Sateesh Kumar Vemula, Krizia Karry, Michael A. Repka
Format: Article
Idioma:English
Publicat: MDPI AG 2024-12-01
Col·lecció:Pharmaceutics
Matèries:
twin screw melt granulation
hot-melt extrusion
amorphous solid dispersion
Soluplus
Kollicoat IR
solubility enhancement
Accés en línia:https://www.mdpi.com/1999-4923/16/12/1630

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https://www.mdpi.com/1999-4923/16/12/1630

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