Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

<b>Background/Objectives:</b> This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability. Additionally, the study e...

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Detalles Bibliográficos
Autores principales: Rasha M. Elkanayati, Indrajeet Karnik, Prateek Uttreja, Nagarjuna Narala, Sateesh Kumar Vemula, Krizia Karry, Michael A. Repka
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2024-12-01
Colección:Pharmaceutics
Materias:
twin screw melt granulation
hot-melt extrusion
amorphous solid dispersion
Soluplus
Kollicoat IR
solubility enhancement
Acceso en línea:https://www.mdpi.com/1999-4923/16/12/1630

Internet

https://www.mdpi.com/1999-4923/16/12/1630

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