A Simple, Cost-Effective, and Extraction-Free Molecular Diagnostic Test for Sickle Cell Disease Using a Noninvasive Buccal Swab Specimen for a Limited-Resource Setting

A Simple, Cost-Effective, and Extraction-Free Molecular Diagnostic Test for Sickle Cell Disease Using a Noninvasive Buccal Swab Specimen for a Limited-Resource Setting

Sickle cell disease (SCD) is the most prevalent life-threatening blood monogenic disorder. Currently, there is no cure available, apart from bone marrow transplantation. Early and efficient diagnosis of SCD is key to disease management, which would make considerable strides in alleviating morbidity...

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Bibliographic Details
Main Authors: Priya Thakur, Pragya Gupta, Nupur Bhargava, Rajat Soni, Narendra Varma Gottumukkala, Sangam Giri Goswami, Gaurav Kharya, Vinodh Saravanakumar, Padma Gunda, Suman Jain, Jasmita Dass, Mukul Aggarwal, Sivaprakash Ramalingam
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Diagnostics
Subjects:
molecular diagnostic test
sickle cell disease
non-invasive
isothermal DNA amplification
buccal swab
extraction-free
Online Access:https://www.mdpi.com/2075-4418/12/7/1765

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