Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis
Abstract Background Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in field of SCI. The objective of this systematic review is to determine the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-023-02306-1 |
| _version_ | 1797453735850409984 |
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| author | Xiao-bo Wang Long-yun Zhou Xu-qing Chen Ran Li Bin-bin Yu Meng-xiao Pan Lu Fang Jian Li Xue-jun Cui Min Yao Xiao Lu |
| author_facet | Xiao-bo Wang Long-yun Zhou Xu-qing Chen Ran Li Bin-bin Yu Meng-xiao Pan Lu Fang Jian Li Xue-jun Cui Min Yao Xiao Lu |
| author_sort | Xiao-bo Wang |
| collection | DOAJ |
| description | Abstract Background Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in field of SCI. The objective of this systematic review is to determine the neuroprotective effects and discuss the underlying mechanism of edaravone in management of SCI. Methods The systematic review will include the controlled studies evaluating the neurological roles of edaravone on experiment rat models following SCI. The primary outcome will be the 21-point Basso, Beattie, and Bresnahan locomotor rating scale. The secondary outcomes will include the preservation of white matter areas and malondialdehyde levels. Two researchers will independently search PubMed, Embase, Web of Science, Scopus and Cochrane Library from their inception date. Following study selection, data extraction, and assessment of methodological quality in included studies using the SYRCLE’s RoB tool, data from eligible studies will be pooled and analyzed using random-effects models with RevMan 5.3 software. In case of sufficient data, subgroup analyses with respect to species, age, gender, injury characteristics, or administration details will be carried out to explore the factors modifying efficacy of edaravone. For exploring the appropriate dose of edaravone, a network meta-analysis approach will be conducted based on the Bayesian method. Importantly, the proposed mechanisms and changes of related molecules will be also extracted from included studies for comprehensively investigating the mechanisms underlying the neuroprotective effects of edaravone. Discussion In this study, we aim to quantitatively analyze the role of edaravone in locomotor recovery and tissue damage in SCI rat model. The efficacy of edaravone in distinct scenarios will be investigated by subgroup analyses, and we expect to predict the candidate dose that offers a superior treatment effect using network meta-analyses. Moreover, a comprehensive framework regarding the neuroprotective mechanisms behind edaravone will be constructed via a combination of systematic and traditional review. This study will bring implications for future preclinical studies and clinical applications of SCI. Nonetheless, in light of the anticipated limitations in animal experimental design and methodological quality, the results in this review should be interpreted with caution. |
| first_indexed | 2024-03-09T15:27:09Z |
| format | Article |
| id | doaj.art-5380b4d22e24452ca1e2020e5ec27c46 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-03-09T15:27:09Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-5380b4d22e24452ca1e2020e5ec27c462023-11-26T12:28:47ZengBMCSystematic Reviews2046-40532023-09-011211710.1186/s13643-023-02306-1Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysisXiao-bo Wang0Long-yun Zhou1Xu-qing Chen2Ran Li3Bin-bin Yu4Meng-xiao Pan5Lu Fang6Jian Li7Xue-jun Cui8Min Yao9Xiao Lu10Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Otolaryngology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese MedicineTraditional Chinese Medicine Hospital of LuAnDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical UniversitySpine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineSpine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Background Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in field of SCI. The objective of this systematic review is to determine the neuroprotective effects and discuss the underlying mechanism of edaravone in management of SCI. Methods The systematic review will include the controlled studies evaluating the neurological roles of edaravone on experiment rat models following SCI. The primary outcome will be the 21-point Basso, Beattie, and Bresnahan locomotor rating scale. The secondary outcomes will include the preservation of white matter areas and malondialdehyde levels. Two researchers will independently search PubMed, Embase, Web of Science, Scopus and Cochrane Library from their inception date. Following study selection, data extraction, and assessment of methodological quality in included studies using the SYRCLE’s RoB tool, data from eligible studies will be pooled and analyzed using random-effects models with RevMan 5.3 software. In case of sufficient data, subgroup analyses with respect to species, age, gender, injury characteristics, or administration details will be carried out to explore the factors modifying efficacy of edaravone. For exploring the appropriate dose of edaravone, a network meta-analysis approach will be conducted based on the Bayesian method. Importantly, the proposed mechanisms and changes of related molecules will be also extracted from included studies for comprehensively investigating the mechanisms underlying the neuroprotective effects of edaravone. Discussion In this study, we aim to quantitatively analyze the role of edaravone in locomotor recovery and tissue damage in SCI rat model. The efficacy of edaravone in distinct scenarios will be investigated by subgroup analyses, and we expect to predict the candidate dose that offers a superior treatment effect using network meta-analyses. Moreover, a comprehensive framework regarding the neuroprotective mechanisms behind edaravone will be constructed via a combination of systematic and traditional review. This study will bring implications for future preclinical studies and clinical applications of SCI. Nonetheless, in light of the anticipated limitations in animal experimental design and methodological quality, the results in this review should be interpreted with caution.https://doi.org/10.1186/s13643-023-02306-1EdaravoneSpinal cord injuryNeuroprotective effectRatProtocolSystematic review |
| spellingShingle | Xiao-bo Wang Long-yun Zhou Xu-qing Chen Ran Li Bin-bin Yu Meng-xiao Pan Lu Fang Jian Li Xue-jun Cui Min Yao Xiao Lu Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis Systematic Reviews Edaravone Spinal cord injury Neuroprotective effect Rat Protocol Systematic review |
| title | Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis |
| title_full | Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis |
| title_fullStr | Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis |
| title_short | Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis |
| title_sort | neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury a protocol for a systematic review and meta analysis |
| topic | Edaravone Spinal cord injury Neuroprotective effect Rat Protocol Systematic review |
| url | https://doi.org/10.1186/s13643-023-02306-1 |
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