Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target
Peritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30−150 nm in diameter secreted by different cell types and internalized by target cells. There is emerging evidence that exo...
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| Format: | Article |
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MDPI AG
2019-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/8/1147 |
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| author | Koji Nakamura Kenjiro Sawada Masaki Kobayashi Mayuko Miyamoto Aasa Shimizu Misa Yamamoto Yasuto Kinose Tadashi Kimura |
| author_facet | Koji Nakamura Kenjiro Sawada Masaki Kobayashi Mayuko Miyamoto Aasa Shimizu Misa Yamamoto Yasuto Kinose Tadashi Kimura |
| author_sort | Koji Nakamura |
| collection | DOAJ |
| description | Peritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30−150 nm in diameter secreted by different cell types and internalized by target cells. There is emerging evidence that exosomes facilitate the peritoneal dissemination of ovarian cancer by mediating intercellular communication between cancer cells and the tumor microenvironment through the transfer of nucleic acids, proteins, and lipids. Furthermore, therapeutic applications of exosomes as drug cargo delivery are attracting research interest because exosomes are stabilized in circulation. This review highlights the functions of exosomes in each process of the peritoneal dissemination of ovarian cancer and discusses their potential for cancer therapeutics. |
| first_indexed | 2024-03-12T07:34:04Z |
| format | Article |
| id | doaj.art-53817fe633cc4985881b4c0622b1697a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:34:04Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-53817fe633cc4985881b4c0622b1697a2023-09-02T21:34:41ZengMDPI AGCancers2072-66942019-08-01118114710.3390/cancers11081147cancers11081147Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic TargetKoji Nakamura0Kenjiro Sawada1Masaki Kobayashi2Mayuko Miyamoto3Aasa Shimizu4Misa Yamamoto5Yasuto Kinose6Tadashi Kimura7Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 5650871, JapanPeritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30−150 nm in diameter secreted by different cell types and internalized by target cells. There is emerging evidence that exosomes facilitate the peritoneal dissemination of ovarian cancer by mediating intercellular communication between cancer cells and the tumor microenvironment through the transfer of nucleic acids, proteins, and lipids. Furthermore, therapeutic applications of exosomes as drug cargo delivery are attracting research interest because exosomes are stabilized in circulation. This review highlights the functions of exosomes in each process of the peritoneal dissemination of ovarian cancer and discusses their potential for cancer therapeutics.https://www.mdpi.com/2072-6694/11/8/1147exosomeovarian cancerperitoneal dissemination |
| spellingShingle | Koji Nakamura Kenjiro Sawada Masaki Kobayashi Mayuko Miyamoto Aasa Shimizu Misa Yamamoto Yasuto Kinose Tadashi Kimura Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target Cancers exosome ovarian cancer peritoneal dissemination |
| title | Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target |
| title_full | Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target |
| title_fullStr | Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target |
| title_full_unstemmed | Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target |
| title_short | Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target |
| title_sort | role of the exosome in ovarian cancer progression and its potential as a therapeutic target |
| topic | exosome ovarian cancer peritoneal dissemination |
| url | https://www.mdpi.com/2072-6694/11/8/1147 |
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