A New Model to Calibrate a Reference Standard for Bovine Tuberculin Purified Protein Derivative in the Target Species

A New Model to Calibrate a Reference Standard for Bovine Tuberculin Purified Protein Derivative in the Target Species

Since 1986, use of a Bovine International Standard (BIS) for bovine tuberculin has been required to ensure national and international uniformity regarding the potency designation of bovine tuberculin Purified Protein Derivative (PPDb) preparations produced by multiple manufacturers. The BIS is the u...

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Bibliographic Details
Main Authors: Klaas Frankena, Liesbeth Jacobs, Tonny van Dijk, Margaret Good, Anthony Duignan, Mart C. M. de Jong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Veterinary Science
Subjects:
mycobacterium bovis
tuberculin
bovine international standard
new reference standard
potency estimation
guinea pigs
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2018.00232/full

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